Anti-AUH antibody [EPR11086(B)] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

AUH also known as AU-specific RNA binding protein/enoyl-CoA hydratase is a bifunctional protein with a molecular mass of approximately 39 kDa. It plays an important role in RNA binding and hydratase activities. AUH is expressed in many tissues including liver brain and heart providing its multiple functional capacities within cells. It binds to AU-rich elements present in mRNA which has significant influence on mRNA stability and turnover. The protein also acts as an enoyl-CoA hydratase involved in the leucine catabolic process.

Biological function summary

The AUH protein is involved in regulating the stability of mRNA by binding to AU-rich elements. This activity is critical for controlling genes expression as it modulates the decay rate of various mRNAs involved in cellular responses. While AUH functions largely independently it may interact with other proteins transiently to exert its RNA binding activity although it is not a part of a stable protein complex. Its hydratase function contributes to the breaking down of leucine an essential amino acid further highlighting its multifaceted biological roles.

Pathways

AUH is interwoven with essential metabolic and gene expression pathways. The protein aligns heavily within the leucine catabolism pathway contributing to the conversion of leucine to acetoacetate and acetyl-CoA which are key intermediates in energy production. AUH's involvement in mRNA decay processes connects it to pathways regulating apoptosis and proliferation where precise control of mRNA turnover by AUH and its related proteins like HuR is essential for cellular outcome.

Associated diseases and disorders

AUH is linked to a rare genetic disorder known as 3-Methylglutaconic aciduria type 1 (MGA-1) characterized by metabolic anomalies manifesting due to defective leucine catabolism. Mutations in the AUH gene disrupt normal protein function leading to accumulation of metabolic intermediates. Furthermore AUH's role in mRNA regulation implies a connection to cancer where altered expression or mutation might contribute to disruptions in gene expression control. Associated proteins in these contexts include components of the mRNA decay pathway and enzymes involved in amino acid metabolism.