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AB96326

Anti-AUTS2 antibody

5

(1 Review)

|

(5 Publications)

Rabbit Polyclonal AUTS2 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AUTS2 aa 500-800.

View Alternative Names

KIAA0442, AUTS2, Autism susceptibility gene 2 protein

1 Images
Western blot - Anti-AUTS2 antibody (AB96326)
  • WB

Unknown

Western blot - Anti-AUTS2 antibody (AB96326)

All lanes:

Western blot - Anti-AUTS2 antibody (ab96326) at 1/1000 dilution

All lanes:

NIH3T3 cell lysate at 30 µg

Predicted band size: 139 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human AUTS2 aa 500-800. The exact immunogen used to generate this antibody is proprietary information.

Q8WXX7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AUTS2 also known as the Autism Susceptibility Gene 2 is a protein encoded by the AUTS2 gene and has a mass of approximately 141 kDa. This protein is expressed in several regions of the brain including the cerebral cortex hippocampus and cerebellum. It plays a role in neuronal development where it impacts neural progenitor cell proliferation and differentiation. Expression of AUTS2 is often regulated during key neurodevelopmental stages.
Biological function summary

The AUTS2 protein is involved in chromatin remodeling impacting gene expression regulation during brain development. It functions as part of a complex involving other transcription factors and regulators to influence diverse neural processes. This involvement in chromatin remodeling highlights its role in controlling when and how genes are activated within cells impacting neurodevelopmental processes significantly.

Pathways

AUTS2 participates in the regulation of neuronal signaling pathways such as the Wnt signaling pathway which is key for cell fate determination during development. Proteins like TCF/LEF are related to AUTS2 through the Wnt signaling pathway where they serve as transcriptional mediators affected by the pathway's activity. This connection indicates AUTS2's role in maintaining the balance between progenitor cell proliferation and differentiation in neural tissues.

AUTS2 has a significant association with autism spectrum disorders (ASD) and intellectual disability. Disruptions or mutations in the AUTS2 gene often associate with these neurodevelopmental conditions. The protein also has connections with other proteins like CHD8 which is often mutated in autism suggesting that alterations affecting AUTS2 could influence broader functional networks in the brain responsible for cognitive development and behavior.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed : 25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed : 25519132). As a consequence, the complex mediates transcriptional activation (PubMed : 25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity).
See full target information AUTS2
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Genetics 221: PubMed35731217

2022

FMRP-dependent production of large dosage-sensitive proteins is highly conserved.

Applications

Unspecified application

Species

Unspecified reactive species

Keegan Flanagan,Alireza Baradaran-Heravi,Qi Yin,Khanh Dao Duc,Allan C Spradling,Ethan J Greenblatt

Science advances 8:eabk0013 PubMed35333572

2022

Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human naïve pluripotent cell reprogramming.

Applications

Unspecified application

Species

Unspecified reactive species

Amanda J Collier,Adam Bendall,Charlene Fabian,Andrew A Malcolm,Katarzyna Tilgner,Claudia I Semprich,Katarzyna Wojdyla,Paola Serena Nisi,Kamal Kishore,Valar Nila Roamio Franklin,Bahar Mirshekar-Syahkal,Clive D'Santos,Kathrin Plath,Kosuke Yusa,Peter J Rugg-Gunn

Molecular psychiatry : PubMed30953002

2019

AUTS2 isoforms control neuronal differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Galya Monderer-Rothkoff,Nitzan Tal,Marina Risman,Odem Shani,Malka Nissim-Rafinia,Laura Malki-Feldman,Vera Medvedeva,Matthias Groszer,Eran Meshorer,Sagiv Shifman

Neuroscience 333:35-43 PubMed27423627

2016

AUTS2 in the nucleus accumbens is essential for heroin-induced behavioral sensitization.

Applications

Unspecified application

Species

Unspecified reactive species

Yongsheng Zhu,Bo Xing,Wei Dang,Yuanyuan Ji,Peng Yan,Yunxiao Li,Xiaomeng Qiao,Jianghua Lai

Translational psychiatry 4:e431 PubMed25180570

2014

Genome-wide distribution of Auts2 binding localizes with active neurodevelopmental genes.

Applications

ChIP

Species

Mouse

N Oksenberg,G D E Haliburton,W L Eckalbar,I Oren,S Nishizaki,K Murphy,K S Pollard,R Y Birnbaum,N Ahituv
View all publications
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