AB108354

Anti-AVEN antibody [EP4721]

RabMAb
Recombinant
What is this?

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(1 Publication)

Rabbit Recombinant Monoclonal AVEN antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Cell death regulator Aven, AVEN

2 Images

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Western blot - Anti-AVEN antibody [EP4721] (AB108354)

All lanes:

Western blot - Anti-AVEN antibody [EP4721] (ab108354) at 1/1000 dilution

Lane 1:

Ramos cell lysate at 10 µg

Lane 2:

Raji cell lysate at 10 µg

Lane 3:

HeLa cell lysate at 10 µg

Predicted band size: 39 kDa

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OI-RD Scanning - Anti-AVEN antibody [EP4721] (AB108354)

OI-RD Scanning

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OI-RD Scanning - Anti-AVEN antibody [EP4721] (AB108354)

We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody. Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.

Carrier free

Anti-AVEN antibody [EP4721] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EP4721

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Conditional Ambient

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AVEN also known as Apoptosis and Caspase Activation Inhibitor is a protein that acts to inhibit apoptotic cell death. It weighs approximately 36 kDa. Expression of AVEN occurs in several tissues including the brain heart and skeletal muscle. Inhibiting apoptosis helps cells survive under stress conditions making AVEN a target of interest for studying cell survival mechanisms.

Biological function summary

The protein serves to safeguard cells from apoptosis. It achieves this by preventing the activation of caspases which are important in the execution of programmed cell death. As part of an apoptosome complex AVEN interacts with apoptotic protease activating factor-1 (Apaf-1) to maintain cell viability under stress conditions and prevent early apoptosis.

Pathways

AVEN integrates into both intrinsic and extrinsic apoptotic pathways. In the intrinsic pathway it associates with proteins like Bcl-2 to maintain mitochondrial integrity and prevent release of cytochrome c. Within the extrinsic pathway AVEN influences Fas receptor-mediated caspase activation which further showcases its role in regulating cell death and survival decisions in response to external signals.

AVEN expression exhibits implications in cancer and neurodegenerative disorders. Dysregulation of AVEN expression links to various cancers as its apoptosis-inhibiting function promotes tumor cell survival. Additionally AVEN interacts with proteins like Bcl-2 in neurodegenerative disorders such as Alzheimer’s where disrupted apoptosis is a critical factor. Understanding AVEN's function helps in advancing targeted therapies and diagnostics in these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Protects against apoptosis mediated by Apaf-1.

See full target information Cell death regulator Aven

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of nanobiotechnology 22:803 PubMed39734237

2024

Targeting AURKA with multifunctional nanoparticles in CRPC therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Deng,Binghu Ke,Qixing Tian,Yukui Gao,Qiliang Zhai,Wenqiang Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-AVEN antibody [EP4721]

Western blot - Anti-AVEN antibody [EP4721] (AB108354)

OI-RD Scanning - Anti-AVEN antibody [EP4721] (AB108354)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Reagents, Controls & Accessories

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise