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Rabbit Polyclonal AVPR1A/V1aR antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human AVPR1A.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AVPR1A/V1aR antibody (AB140492), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Synthetic Peptide within Human AVPR1A. The exact immunogen used to generate this antibody is proprietary information. Database link P37288

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested
Gorilla
Predicted
Monkey
Predicted

Tested
Tested

Species
Human
Dilution info
2.5 µg/mL
Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Predicted
Predicted

Species
Monkey, Gorilla
Dilution info
-
Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.

Alternative names

Recommended products

Rabbit Polyclonal AVPR1A/V1aR antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human AVPR1A.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Synthetic Peptide within Human AVPR1A. The exact immunogen used to generate this antibody is proprietary information. Database link P37288
Purification technique
Affinity purification Immunogen
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

The AVPR1A also known as V1aR is a receptor for the hormone arginine vasopressin displaying a molecular mass of approximately 41 kDa. It belongs to the class of G protein-coupled receptors and is expressed mainly in the liver kidney brain and vascular smooth muscle cells. This receptor binds vasopressin with high affinity and mediates its effects through the activation of phospholipase C leading to the generation of inositol triphosphate and diacylglycerol.

Biological function summary

AVPR1A affects cardiovascular renal and central nervous system functions. It does not form part of a complex but plays a critical role in the regulation of blood pressure water retention and social behaviors. The receptor mediates vasoconstriction and increases water reabsorption in the kidneys impacting fluid balance and vascular tone.

Pathways

AVPR1A is an important component in pathways like the vasopressin-regulated sodium concentration and ventricular hypertrophy pathways. It interacts with proteins such as Gq/11 which initiates signaling cascades leading to effects on vascular contraction and myocardium remodeling. The AVPR1A signals alongside other receptors like the V2 vasopressin receptor contributing to different physiological outcomes.

Associated diseases and disorders

AVPR1A is linked to conditions such as hypertension and autism spectrum disorder. In hypertension the receptor's role in vasoconstriction and fluid homeostasis links it with high blood pressure. Research indicates a possible association with autism linking social behavior modulation through oxytocin and vasopressin pathways. In both diseases AVPR1A interacts with other proteins like the oxytocin receptor shaping its influence on pathophysiological processes.

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AVPR1A/V1aR antibody (ab140492), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AVPR1A/V1aR antibody (ab140492)

    Immunohistochemical analysis of formalin fixed, paraffin embedded Human kidney tissue labelling AVPR1A/V1aR with ab140492 at 2.5 μg/ml.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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