Rabbit Polyclonal AVPR1A/V1aR antibody. Suitable for WB and reacts with Rat samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Rat Avpr1a aa 150-200.
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- The journal of headache and pain 23:1522022Expression of vasopressin and its receptors in migraine-related regions in CNS and the trigeminal system: influence of sex.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAida Maddahi,Lars Edvinsson,Karin WarfvingePubMed 36456902
- Frontiers in zoology 18:562021Population variation alters aggression-associated oxytocin and vasopressin expressions in brains of Brandt's voles in field conditions.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShuli Huang,Guoliang Li,Yongliang Pan,Jing Liu,Jidong Zhao,Xin Zhang,Wei Lu,Xinrong Wan,Charles J Krebs,Zuoxin Wang,Wenxuan Han,Zhibin ZhangPubMed 34717666
- Oxidative medicine and cellular longevity 2020:88502662020Fluid Intake Restriction Concomitant to Sweetened Beverages Hydration Induce Kidney Damage.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFernando E García-Arroyo et. al.PubMed 33354281
- Integrative zoology 16:149-1592020Density-induced social stress alters oxytocin and vasopressin activities in the brain of a small rodent species.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShuli Huang,Guoliang Li,Yongliang Pan,Mingjing Song,Jidong Zhao,Xinrong Wan,Charles J Krebs,Zuoxin Wang,Wenxuan Han,Zhibin ZhangPubMed 32652776
- The ISME journal 14:2625-26452020Coprophagy prevention alters microbiome, metabolism, neurochemistry, and cognitive behavior in a small mammal.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTing-Bei Bo,Xue-Ying Zhang,Kevin D Kohl,Jing Wen,Shuang-Jie Tian,De-Hua WangPubMed 32632263
- International journal of molecular sciences 20:2019A Role for Both V1a and V2 Receptors in Renal Heat Stress Injury Amplified by Rehydration with Fructose.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFernando E García-Arroyo et. al.PubMed 31744099
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Rat Avpr1a aa 150-200. The exact immunogen used to generate this antibody is proprietary information. Database link P30560
Reactivity data
Select an application| WB | |
|---|---|
| Mouse | Predicted |
| Rat | Tested |
| Sheep | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 0.10000-0.50000 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Sheep | Dilution info - | Notes - |
Associated Products
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2 products for Alternative Product
Target data
Function
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.
Alternative names
Vasopressin V1a receptor, V1aR, AVPR V1a, Antidiuretic hormone receptor 1a, Vascular/hepatic-type arginine vasopressin receptor, Avpr1a
Recommended products
Rabbit Polyclonal AVPR1A/V1aR antibody. Suitable for WB and reacts with Rat samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Rat Avpr1a aa 150-200.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Rat Avpr1a aa 150-200. The exact immunogen used to generate this antibody is proprietary information. Database link P30560
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The AVPR1A also known as V1aR is a receptor for the hormone arginine vasopressin displaying a molecular mass of approximately 41 kDa. It belongs to the class of G protein-coupled receptors and is expressed mainly in the liver kidney brain and vascular smooth muscle cells. This receptor binds vasopressin with high affinity and mediates its effects through the activation of phospholipase C leading to the generation of inositol triphosphate and diacylglycerol.
- Biological function summary
AVPR1A affects cardiovascular renal and central nervous system functions. It does not form part of a complex but plays a critical role in the regulation of blood pressure water retention and social behaviors. The receptor mediates vasoconstriction and increases water reabsorption in the kidneys impacting fluid balance and vascular tone.
- Pathways
AVPR1A is an important component in pathways like the vasopressin-regulated sodium concentration and ventricular hypertrophy pathways. It interacts with proteins such as Gq/11 which initiates signaling cascades leading to effects on vascular contraction and myocardium remodeling. The AVPR1A signals alongside other receptors like the V2 vasopressin receptor contributing to different physiological outcomes.
- Associated diseases and disorders
AVPR1A is linked to conditions such as hypertension and autism spectrum disorder. In hypertension the receptor's role in vasoconstriction and fluid homeostasis links it with high blood pressure. Research indicates a possible association with autism linking social behavior modulation through oxytocin and vasopressin pathways. In both diseases AVPR1A interacts with other proteins like the oxytocin receptor shaping its influence on pathophysiological processes.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-AVPR1A/V1aR antibody (ab187753)
All lanes: Western blot - Anti-AVPR1A/V1aR antibody (ab187753) at 0.5 µg/mL
Lane 1: Rat Liver Tissue Lysate at 40 µg
Lane 2: Rat Kidney Tissue Lysate at 40 µg
Predicted band size: 47 kDa
Observed band size: 47 kDa
Image collected and cropped by CiteAb under a CC-BY license from the publication
Western blot - Anti-AVPR1A/V1aR antibody (ab187753)
AVPR1A/V1aR western blot using anti-AVPR1A/V1aR antibody ab187753. Publication image and figure legend from García-Arroyo, F. E., Muñoz-Jiménez, I., et al., 2019, Int J Mol Sci, PubMed 31744099.
ab187753 was used in this publication in western blot. This may not be the same as the application(s) guaranteed by Abcam. For a full list of applications guaranteed by Abcam for ab187753 please see the product overview.
Plasma copeptin and vasopressin receptors expression in the renal cortex. (A) Plasma copeptin was increased in heat-stressed rats rehydrated with the fructose beverage, regardless of relcovaptan or tolvaptan treatment. V1a receptor (B) and V2 receptor (C) expressions were increased by heat stress and fructose beverage rehydration. Relcovaptan partially prevented V1a overexpression (B), and tolvaptan fully prevented V2 overexpression (C). (D) Likewise, only tolvaptan prevented the increment of cAMP in the non-proximal tubule fraction induced by heat stress and rehydration with the fructose beverage. For western-blot, three random samples per group were selected. Proteins of interest and the respective loading controls were run independently at the same time using the same conditions. The raw dataset is available in the Supplementary Materials.
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