Anti-AVPR1A/V1aR antibody
2
(2 Reviews)
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(7 Publications)
Rabbit Polyclonal AVPR1A/V1aR antibody. Suitable for WB and reacts with Rat samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Rat Avpr1a aa 150-200.
View Alternative Names
Vasopressin V1a receptor, V1aR, AVPR V1a, Antidiuretic hormone receptor 1a, Vascular/hepatic-type arginine vasopressin receptor, Avpr1a
- WB
Supplier Data
Western blot - Anti-AVPR1A/V1aR antibody (AB187753)
All lanes:
Western blot - Anti-AVPR1A/V1aR antibody (ab187753) at 0.5 µg/mL
Lane 1:
Rat Liver Tissue Lysate at 40 µg
Lane 2:
Rat Kidney Tissue Lysate at 40 µg
Predicted band size: 47 kDa
Observed band size: 47 kDa
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- WB
CiteAb
Western blot - Anti-AVPR1A/V1aR antibody (AB187753)
AVPR1A/V1aR western blot using anti-AVPR1A/V1aR antibody ab187753. Publication image and figure legend from García-Arroyo, F. E., Muñoz-Jiménez, I., et al., 2019, Int J Mol Sci, PubMed 31744099.
ab187753 was used in this publication in western blot. This may not be the same as the application(s) guaranteed by Abcam. For a full list of applications guaranteed by Abcam for ab187753 please see the product overview.
Plasma copeptin and vasopressin receptors expression in the renal cortex. (A) Plasma copeptin was increased in heat-stressed rats rehydrated with the fructose beverage, regardless of relcovaptan or tolvaptan treatment. V1a receptor (B) and V2 receptor (C) expressions were increased by heat stress and fructose beverage rehydration. Relcovaptan partially prevented V1a overexpression (B), and tolvaptan fully prevented V2 overexpression (C). (D) Likewise, only tolvaptan prevented the increment of cAMP in the non-proximal tubule fraction induced by heat stress and rehydration with the fructose beverage. For western-blot, three random samples per group were selected. Proteins of interest and the respective loading controls were run independently at the same time using the same conditions. The raw dataset is available in the Supplementary Materials.
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Reactivity data
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Biological function summary
AVPR1A affects cardiovascular renal and central nervous system functions. It does not form part of a complex but plays a critical role in the regulation of blood pressure water retention and social behaviors. The receptor mediates vasoconstriction and increases water reabsorption in the kidneys impacting fluid balance and vascular tone.
Pathways
AVPR1A is an important component in pathways like the vasopressin-regulated sodium concentration and ventricular hypertrophy pathways. It interacts with proteins such as Gq/11 which initiates signaling cascades leading to effects on vascular contraction and myocardium remodeling. The AVPR1A signals alongside other receptors like the V2 vasopressin receptor contributing to different physiological outcomes.
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Publications (7)
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The journal of headache and pain 23:152 PubMed36456902
2022
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Frontiers in zoology 18:56 PubMed34717666
2021
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Oxidative medicine and cellular longevity 2020:8850266 PubMed33354281
2020
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Integrative zoology 16:149-159 PubMed32652776
2020
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The ISME journal 14:2625-2645 PubMed32632263
2020
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International journal of molecular sciences 20: PubMed31744099
2019
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Experimental and therapeutic medicine 11:1788-1794 PubMed27168804
2016
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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