Anti-AVPR1A/V1aR antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The AVPR1A also known as V1aR is a receptor for the hormone arginine vasopressin displaying a molecular mass of approximately 41 kDa. It belongs to the class of G protein-coupled receptors and is expressed mainly in the liver kidney brain and vascular smooth muscle cells. This receptor binds vasopressin with high affinity and mediates its effects through the activation of phospholipase C leading to the generation of inositol triphosphate and diacylglycerol.

Biological function summary

AVPR1A affects cardiovascular renal and central nervous system functions. It does not form part of a complex but plays a critical role in the regulation of blood pressure water retention and social behaviors. The receptor mediates vasoconstriction and increases water reabsorption in the kidneys impacting fluid balance and vascular tone.

Pathways

AVPR1A is an important component in pathways like the vasopressin-regulated sodium concentration and ventricular hypertrophy pathways. It interacts with proteins such as Gq/11 which initiates signaling cascades leading to effects on vascular contraction and myocardium remodeling. The AVPR1A signals alongside other receptors like the V2 vasopressin receptor contributing to different physiological outcomes.

Associated diseases and disorders

AVPR1A is linked to conditions such as hypertension and autism spectrum disorder. In hypertension the receptor's role in vasoconstriction and fluid homeostasis links it with high blood pressure. Research indicates a possible association with autism linking social behavior modulation through oxytocin and vasopressin pathways. In both diseases AVPR1A interacts with other proteins like the oxytocin receptor shaping its influence on pathophysiological processes.