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AB187753

Anti-AVPR1A/V1aR antibody

2

(2 Reviews)

|

(7 Publications)

Rabbit Polyclonal AVPR1A/V1aR antibody. Suitable for WB and reacts with Rat samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Rat Avpr1a aa 150-200.

View Alternative Names

Vasopressin V1a receptor, V1aR, AVPR V1a, Antidiuretic hormone receptor 1a, Vascular/hepatic-type arginine vasopressin receptor, Avpr1a

2 Images
Western blot - Anti-AVPR1A/V1aR antibody (AB187753)
  • WB

Supplier Data

Western blot - Anti-AVPR1A/V1aR antibody (AB187753)

All lanes:

Western blot - Anti-AVPR1A/V1aR antibody (ab187753) at 0.5 µg/mL

Lane 1:

Rat Liver Tissue Lysate at 40 µg

Lane 2:

Rat Kidney Tissue Lysate at 40 µg

Predicted band size: 47 kDa

Observed band size: 47 kDa

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Western blot - Anti-AVPR1A/V1aR antibody (AB187753)
  • WB

CiteAb

Western blot - Anti-AVPR1A/V1aR antibody (AB187753)

AVPR1A/V1aR western blot using anti-AVPR1A/V1aR antibody ab187753. Publication image and figure legend from García-Arroyo, F. E., Muñoz-Jiménez, I., et al., 2019, Int J Mol Sci, PubMed 31744099.

ab187753 was used in this publication in western blot. This may not be the same as the application(s) guaranteed by Abcam. For a full list of applications guaranteed by Abcam for ab187753 please see the product overview.

Plasma copeptin and vasopressin receptors expression in the renal cortex. (A) Plasma copeptin was increased in heat-stressed rats rehydrated with the fructose beverage, regardless of relcovaptan or tolvaptan treatment. V1a receptor (B) and V2 receptor (C) expressions were increased by heat stress and fructose beverage rehydration. Relcovaptan partially prevented V1a overexpression (B), and tolvaptan fully prevented V2 overexpression (C). (D) Likewise, only tolvaptan prevented the increment of cAMP in the non-proximal tubule fraction induced by heat stress and rehydration with the fructose beverage. For western-blot, three random samples per group were selected. Proteins of interest and the respective loading controls were run independently at the same time using the same conditions. The raw dataset is available in the Supplementary Materials.

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Rat Avpr1a aa 150-200. The exact immunogen used to generate this antibody is proprietary information.

P30560

Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The AVPR1A also known as V1aR is a receptor for the hormone arginine vasopressin displaying a molecular mass of approximately 41 kDa. It belongs to the class of G protein-coupled receptors and is expressed mainly in the liver kidney brain and vascular smooth muscle cells. This receptor binds vasopressin with high affinity and mediates its effects through the activation of phospholipase C leading to the generation of inositol triphosphate and diacylglycerol.
Biological function summary

AVPR1A affects cardiovascular renal and central nervous system functions. It does not form part of a complex but plays a critical role in the regulation of blood pressure water retention and social behaviors. The receptor mediates vasoconstriction and increases water reabsorption in the kidneys impacting fluid balance and vascular tone.

Pathways

AVPR1A is an important component in pathways like the vasopressin-regulated sodium concentration and ventricular hypertrophy pathways. It interacts with proteins such as Gq/11 which initiates signaling cascades leading to effects on vascular contraction and myocardium remodeling. The AVPR1A signals alongside other receptors like the V2 vasopressin receptor contributing to different physiological outcomes.

AVPR1A is linked to conditions such as hypertension and autism spectrum disorder. In hypertension the receptor's role in vasoconstriction and fluid homeostasis links it with high blood pressure. Research indicates a possible association with autism linking social behavior modulation through oxytocin and vasopressin pathways. In both diseases AVPR1A interacts with other proteins like the oxytocin receptor shaping its influence on pathophysiological processes.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.
See full target information Avpr1a

Publications (7)

Recent publications for all applications. Explore the full list and refine your search

The journal of headache and pain 23:152 PubMed36456902

2022

Expression of vasopressin and its receptors in migraine-related regions in CNS and the trigeminal system: influence of sex.

Applications

Unspecified application

Species

Unspecified reactive species

Aida Maddahi,Lars Edvinsson,Karin Warfvinge

Frontiers in zoology 18:56 PubMed34717666

2021

Population variation alters aggression-associated oxytocin and vasopressin expressions in brains of Brandt's voles in field conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Shuli Huang,Guoliang Li,Yongliang Pan,Jing Liu,Jidong Zhao,Xin Zhang,Wei Lu,Xinrong Wan,Charles J Krebs,Zuoxin Wang,Wenxuan Han,Zhibin Zhang

Oxidative medicine and cellular longevity 2020:8850266 PubMed33354281

2020

Fluid Intake Restriction Concomitant to Sweetened Beverages Hydration Induce Kidney Damage.

Applications

Unspecified application

Species

Unspecified reactive species

Fernando E García-Arroyo,Edilia Tapia,Itzel Muñoz-Jiménez,Guillermo Gonzaga-Sánchez,Abraham S Arellano-Buendía,Horacio Osorio-Alonso,Lino Manterola-Romero,Carlos A Roncal-Jiménez,Richard J Johnson,Laura G Sánchez-Lozada

Integrative zoology 16:149-159 PubMed32652776

2020

Density-induced social stress alters oxytocin and vasopressin activities in the brain of a small rodent species.

Applications

Unspecified application

Species

Unspecified reactive species

Shuli Huang,Guoliang Li,Yongliang Pan,Mingjing Song,Jidong Zhao,Xinrong Wan,Charles J Krebs,Zuoxin Wang,Wenxuan Han,Zhibin Zhang

The ISME journal 14:2625-2645 PubMed32632263

2020

Coprophagy prevention alters microbiome, metabolism, neurochemistry, and cognitive behavior in a small mammal.

Applications

Unspecified application

Species

Unspecified reactive species

Ting-Bei Bo,Xue-Ying Zhang,Kevin D Kohl,Jing Wen,Shuang-Jie Tian,De-Hua Wang

International journal of molecular sciences 20: PubMed31744099

2019

A Role for Both V1a and V2 Receptors in Renal Heat Stress Injury Amplified by Rehydration with Fructose.

Applications

Unspecified application

Species

Unspecified reactive species

Fernando E García-Arroyo,Itzel Muñoz-Jiménez,Guillermo Gonzaga,Edilia Tapia,Horacio Osorio-Alonso,Carlos A Roncal-Jiménez,Alison Iroz,Mariacristina Vecchio,Juan G Reyes-García,Richard J Johnson,L Gabriela Sánchez-Lozada

Experimental and therapeutic medicine 11:1788-1794 PubMed27168804

2016

Immunogenicity of varicella zoster virus glycoprotein E DNA vaccine.

Applications

Unspecified application

Species

Unspecified reactive species

Lidao Bao,Guomin Wei,Hongmei Gan,Xianhua Ren,Ruilian Ma,Y I Wang,Haijun Lv
View all publications

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