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AB220989

Anti-AXUD1 antibody

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(1 Publication)

Rabbit Polyclonal AXUD1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CSRNP1 aa 100-200.

View Alternative Names

AXUD1, TAIP3, CSRNP1, Cysteine/serine-rich nuclear protein 1, CSRNP-1, Axin-1 up-regulated gene 1 protein, Protein URAX1, TGF-beta-induced apoptosis protein 3, TAIP-3

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-AXUD1 antibody (AB220989)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-AXUD1 antibody (AB220989)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized U-2 OS cells labeling AXUD1 with ab220989 at 4 μg/ml (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human CSRNP1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q96S65

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Orangutan": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AXUD1 also known as C1orf61 is a protein with a molecular mass of approximately 33 kDa. It plays a role in transcription regulation by acting as a transcription factor. AXUD1 gets expressed in various tissues including notable expression in the brain and certain cancer tissues. It controls gene expression by binding to DNA sequences therefore impacting cell behavior and phenotype.
Biological function summary

AXUD1 participates in cellular responses that involve gene expression changes. It is not reported to form part of any multi-protein complex but interacts with other proteins to exert its function. In the nervous system it contributes to neurite outgrowth which is important for neuron development and function. In cancer cells AXUD1 influences processes that regulate cell proliferation migration and differentiation.

Pathways

The action of AXUD1 links to the Wnt signaling pathway and the sonic hedgehog pathway. The protein supports the regulation of gene expression downstream of these pathways influencing cellular growth and differentiation. Within these pathways AXUD1 interacts with beta-catenin in Wnt signaling facilitating transcriptional activation of target genes. The role in the sonic hedgehog pathway remains less defined but suggests involvement in cell fate determination.

AXUD1 has connections to cancer and neurological disorders. Altered expression levels of AXUD1 appear in several cancer types including glioblastoma and breast cancer suggesting its role in tumor progression. AXUD1 influences cancer by interacting with proteins like p53 a well-known tumor suppressor. Additionally in neurological disorders disruptions in AXUD1 expression or function may contribute to conditions like neurodegenerative diseases affecting proteins involved in neuronal survival and repair.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis.
See full target information CSRNP1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular medicine 47: PubMed33693954

2021

TGIF1 plays a carcinogenic role in esophageal squamous cell carcinoma through the Wnt/β‑catenin and Akt/mTOR signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Lingling Kong,Yang Yu,Hui Guan,Liyang Jiang,Fenghao Sun,Xiaolin Li,Wei Huang,Baosheng Li
View all publications
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