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AB192771

Anti-AZIN2 antibody

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(4 Publications)

Rabbit Polyclonal AZIN2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AZIN2 aa 100-400.

View Alternative Names

ADC, KIAA1945, ODCP, AZIN2, Antizyme inhibitor 2, AzI2, Arginine decarboxylase, Ornithine decarboxylase-like protein, ornithine decarboxylase paralog, ARGDC, ODC-like protein, ODC-p

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AZIN2 antibody (AB192771)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AZIN2 antibody (AB192771)

Immunohistochemistry of formalin-fixed, paraffin-embedded human small intestine labeling AZIN2 with ab192771 at 7.5 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AZIN2 antibody (AB192771)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AZIN2 antibody (AB192771)

Immunohistochemistry of formalin-fixed, paraffin-embedded human liver labeling AZIN2 with ab192771 at 7.5 μg/ml.

Western blot - Anti-AZIN2 antibody (AB192771)
  • WB

Supplier Data

Western blot - Anti-AZIN2 antibody (AB192771)

10% SDS PAGE

All lanes:

Western blot - Anti-AZIN2 antibody (ab192771) at 1/5000 dilution

All lanes:

SK-N-SH whole cell lysate at 30 µg

Predicted band size: 50 kDa

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Western blot - Anti-AZIN2 antibody (AB192771)
  • WB

Supplier Data

Western blot - Anti-AZIN2 antibody (AB192771)

10% SDS PAGE

All lanes:

Western blot - Anti-AZIN2 antibody (ab192771) at 1/1500 dilution

All lanes:

Human normal cerebellar extract at 30 µg

Predicted band size: 50 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human AZIN2 aa 100-400. The exact immunogen used to generate this antibody is proprietary information.

Q96A70

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "7.5 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The biological target AZIN2 also known as Antizyme Inhibitor 2 is a protein that modulates polyamine levels within cells by inhibiting antizyme activity. It weighs approximately 47 kDa. AZIN2 expresses in various tissues including the brain and adrenal glands where its role is closely associated with polyamine biosynthesis. The protein interacts with antizymes to regulate their function which in turn controls the degradation of ornithine decarboxylase and the uptake of polyamines.
Biological function summary

AZIN2 functions as a modulator of the polyamine pathway preventing protein degradation and facilitating cellular growth and proliferation. It is part of a regulatory complex that includes antizymes and affects the homeostasis of polyamines. This complex interplay significantly impacts the cellular environment and plays a role in maintaining cellular function influencing processes such as signal transduction and ion transport.

Pathways

AZIN2's manipulation of the polyamine pathway reveals its role in cellular growth regulation. It participates in the pathway alongside the arginine and proline metabolism influencing the balance of polyamines within cells. AZIN2 shares a relationship with ornithine decarboxylase and antizymes stabilizing polyamine levels critical for DNA stabilization and protein synthesis.

Dysregulation of AZIN2 can relate to cancer and metabolic syndrome. In cancer disrupted polyamine regulation can lead to uncontrolled cell proliferation; AZIN2 affects this through its interaction with antizymes and ornithine decarboxylase. In metabolic syndrome altered polyamine levels associate with energy homeostasis and can implicate AZIN2’s function in disease progression. Understanding these connections provides potential therapeutic avenues for managing such conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed : 17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed : 17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed : 20188728).
See full target information AZIN2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 16:1613438 PubMed40978465

2025

Abnormal Ca handling and reduced I contribute to citalopram-induced QT prolongation and cardiac arrhythmias.

Applications

Unspecified application

Species

Unspecified reactive species

Yangpeng Li,Jiamin Xie,Yuqing Zheng,Jianhong Li,Min Zhao,Li Liu,Hongping Shen,Ming Lei,Xiaoqiu Tan,Juan Xiao,Xueru Liu,Tangting Chen

Scientific reports 15:7481 PubMed40032914

2025

Ornithine decarboxylase antizyme 2 (OAZ2) in human colon adenocarcinoma: a potent prognostic factor associated with immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Yiheng Liu,Shengjie Zhang,Wenjie Liao,Jun Qian,Cuihua Lu,Li Jin

Journal of animal science and biotechnology 12:46 PubMed33827696

2021

Pre-implantation exogenous progesterone and pregnancy in sheep. II. Effects on fetal-placental development and nutrient transporters in late pregnancy.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine M Halloran,Emily C Hoskins,Claire Stenhouse,Robyn M Moses,Kathrin A Dunlap,M Carey Satterfield,Heewon Seo,Gregory A Johnson,Guoyao Wu,Fuller W Bazer

Journal of animal science and biotechnology 12:39 PubMed33663606

2021

Pre-implantation exogenous progesterone and pregnancy in sheep: I. polyamines, nutrient transport, and progestamedins.

Applications

Unspecified application

Species

Unspecified reactive species

Emily C Hoskins,Katherine M Halloran,Claire Stenhouse,Robyn M Moses,Kathrin A Dunlap,Michael C Satterfield,Heewon Seo,Gregory A Johnson,Guoyao Wu,Fuller W Bazer
View all publications
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