Anti-b-Myc antibody [EP643Y]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

B-Myc functions to modulate transcriptional activities that are necessary for cellular homeostasis. It can associate with other proteins and is often considered part of transcriptional repression complexes. These complexes contribute to regulating gene expression achieving this by directly binding to target DNA sequences or interacting with other transcription factors and co-repressors. Its activities significantly impact cellular differentiation and proliferation providing checks and balances against other members of the Myc family that promote cellular growth.

Pathways

B-Myc is involved in pathways that play a critical role in cell cycle regulation and apoptosis. It actively participates in the Myc signaling pathway where its presence helps counterbalance the more proliferative effects of c-Myc and N-Myc. By doing so it interacts with proteins like Max enabling the formation of different dimers with varying transcriptional roles. Additionally b-Myc's activity within these pathways suggests an intriguing role in modulating cellular responses to growth signals and stressors.