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AB75148

Anti-B1R antibody

4

(3 Reviews)

|

(3 Publications)

Rabbit Polyclonal B1R antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human BDKRB1.

View Alternative Names

BRADYB1, BDKRB1, B1 bradykinin receptor, B1R, BK-1 receptor

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-B1R antibody (AB75148)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-B1R antibody (AB75148)

Immunofluorescence analysis of B1R in LOVO cells using ab75148, at 1/500 dilution, with (right panel) or without (left panel) preincubation with the immunizing peptide.

Western blot - Anti-B1R antibody (AB75148)
  • WB

Unknown

Western blot - Anti-B1R antibody (AB75148)

All lanes:

Western blot - Anti-B1R antibody (ab75148) at 1/500 dilution

Lane 1:

Extracts from K562 cells at 25 µg

Lane 2:

Extracts from K562 cells at 25 µg with immunising peptide

Predicted band size: 40 kDa,47 kDa,90 kDa

Observed band size: 40 kDa,48 kDa,49 kDa,50 kDa,82 kDa,91 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Synthetic Peptide within Human BDKRB1. The exact immunogen used to generate this antibody is proprietary information.

P46663

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The B1R also known as B1 kinin receptor is a G protein-coupled receptor involved in the pro-inflammatory response. It has a mass of around 41 kDa and often occurs in low expression under normal physiological conditions. However the expression increases significantly during tissue injury and inflammation. B1R is predominantly expressed in various tissues including vascular endothelial cells smooth muscle and certain immune cells. Its upregulation in inflamed or injured tissues makes it a significant target for therapeutic interventions.
Biological function summary

B1R mediates cellular responses to kinins particularly bradykinin-related peptides that form during inflammation or injury. This receptor does not typically appear as part of a complex acting instead as a stand-alone mediator that influences pain transmission vasodilation and leukocyte recruitment. By engaging with specific ligands B1R contributes to the induction of pro-inflammatory pathways and signals eventual tissue repair.

Pathways

B1R plays an important role in the kinin-kallikrein system and is vital for inflammatory responses. This system includes interactions with kinins such as bradykinin which activates B1R leading to the activation of signaling molecules like protein kinase C (PKC) and phospholipase C (PLC). These kinases further impact various downstream effects including the activation of nuclear factor-kB (NF-kB) that enhance inflammatory responses positioning B1R within broader vascular and inflammatory pathways.

B1R has been associated with inflammatory diseases such as rheumatoid arthritis and diabetic complications. The receptor’s interaction with proteins like NF-kB facilitates inflammation and exacerbates disease progression in these contexts. B1R overexpression can promote chronic inflammation and tissue damage making it a potential target for therapeutic strategies in inflammatory and pain-related disorders seeking to mitigate symptoms by disrupting its pro-inflammatory role.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
See full target information BDKRB1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

BMC biology 23:76 PubMed40075424

2025

Bradykinin's carbamylation as a mechanistic link to impaired wound healing in patients with kidney dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Marta Kaminska,Urszula Kałucka,Janka Babickova,Małgorzata Benedyk-Machaczka,Eleni Skandalou,Melissa M Grant,Hans-Peter Marti,Piotr Mydel

Experimental and therapeutic medicine 22:1240 PubMed34539836

2021

Involvement of bradykinin and bradykinin B1 receptor in patients with endometriosis.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Meng,Ying Li,Qingxue Li,Jian Yang,Mingli An,Xinping Fu,Shuancheng Zhang,Jingwei Chen

Journal of immunology (Baltimore, Md. : 1950) 192:377-84 PubMed24319267

2013

Soluble gC1qR is an autocrine signal that induces B1R expression on endothelial cells.

Applications

WB

Species

Unspecified reactive species

Berhane Ghebrehiwet,Yan Ji,Alisa Valentino,Lina Pednekar,Mahalakshmi Ramadass,David Habiel,Richard R Kew,Kinga H Hosszu,Dennis K Galanakis,Uday Kishore,Ellinor I B Peerschke
View all publications
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