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AB168120

Anti-B27 antibody

2

(1 Review)

|

(1 Publication)

Mouse Polyclonal B27 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MRAP.

View Alternative Names

C21orf61, FALP, MRAP, Melanocortin-2 receptor accessory protein, B27, Fat cell-specific low molecular weight protein, Fat tissue-specific low MW protein

1 Images
Western blot - Anti-B27 antibody (AB168120)
  • WB

Unknown

Western blot - Anti-B27 antibody (AB168120)

All lanes:

Western blot - Anti-B27 antibody (ab168120) at 1 µg/mL

Lane 1:

B27 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG

Predicted band size: 19 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MRAP.

Q8TCY5

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The B27 protein also known as HLA-B27 is a specific allele of the human leukocyte antigen (HLA) class I molecules. This protein has a mass of approximately 45 kDa and is mainly expressed on the surface of nucleated cells especially in immune cells like lymphocytes. HLA-B27 plays an important role in presenting peptides to the immune system enabling the recognition and clearance of pathogens. This expression helps maintain immune surveillance and promotes the initiation of immune responses.
Biological function summary

This protein assists in the regulation of immune system activities. HLA-B27 does so by forming a complex with beta-2 microglobulin and presenting endogenous antigens to CD8+ T cells. This presentation is important for immune regulation and cellular immunity. The ability of HLA-B27 to bind peptides often shapes immunological responses influencing how the immune system reacts to infectious agents and other antigens.

Pathways

This protein significantly integrates into the antigen processing and presentation pathway. It contributes to the adaptive immune response playing a role in the endosomal/lysosomal pathway where intracellular proteins get degraded into peptides. HLA-B27 works closely with other HLA molecules and the transporter associated with antigen processing (TAP) facilitating efficient peptide loading and transport onto the cell surface.

HLA-B27 shows a strong association with several autoimmune conditions including ankylosing spondylitis and reactive arthritis. Genetic studies suggest that misfolded HLA-B27 may lead to endoplasmic reticulum stress influencing cellular processes related to these conditions. Tumor necrosis factor-alpha (TNF-alpha) often interacts with HLA-B27 within these disease contexts which further highlights the protein's involvement in inflammatory pathways and autoimmune manifestations.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.
See full target information MRAP
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of molecular endocrinology 56:69-76 PubMed26576642

2015

H295R expression of melanocortin 2 receptor accessory protein results in ACTH responsiveness.

Applications

Unspecified application

Species

Unspecified reactive species

Kazutaka Nanba,Andrew X Chen,Adina F Turcu,William E Rainey
View all publications
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Product promise

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