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AB188797

Anti-B2R antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal B2R antibody. C-terminal. Suitable for ICC, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human BDKRB2.

View Alternative Names

BKR2, BDKRB2, B2 bradykinin receptor, B2R, BK-2 receptor

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B2R antibody - C-terminal (AB188797)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B2R antibody - C-terminal (AB188797)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human prostrate tissue labeling B2R with ab188797 at 10 μg/ml.

Immunocytochemistry - Anti-B2R antibody - C-terminal (AB188797)
  • ICC

Supplier Data

Immunocytochemistry - Anti-B2R antibody - C-terminal (AB188797)

Immunocytochemical analysis of untransfected HEK293 Human embryonic kidney cells labeling B2R with ab188797 at 10ug/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC, IHC-P

applications

Immunogen

Synthetic Peptide within Human BDKRB2. The exact immunogen used to generate this antibody is proprietary information.

P30411

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except BAHD1 (44%).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "5-15 µg/mL", "ICC-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-10 µg/mL", "IHCP-species-notes": "<p></p>" }, "Common marmoset": { "ICC-species-checked": "predicted", "ICC-species-dilution-info": "", "ICC-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "ICC-species-checked": "predicted", "ICC-species-dilution-info": "", "ICC-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "ICC-species-checked": "predicted", "ICC-species-dilution-info": "", "ICC-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

B2R also known as Bradykinin B2 Receptor is a receptor protein with a mass of approximately 41 kDa. It is part of the G-protein coupled receptor (GPCR) family. B2R receptors are widely expressed in various tissues including the prostate tissue cardiovascular system and central nervous system. This receptor primarily binds to bradykinin a peptide involved in numerous physiological processes.
Biological function summary

B2R plays a pivotal role in mediating responses to bradykinin influencing processes such as vasodilation inflammation and pain. It does not typically form part of a larger complex but operates as a membrane receptor. The interaction of bradykinin with B2R results in cellular responses that include the release of nitric oxide and prostaglandins which are important signaling molecules.

Pathways

B2R is involved in the kinin-kallikrein system and the inflammatory response pathway. In the kinin-kallikrein system B2R interacts with other proteins like kallikreins which activate bradykinin. In the inflammatory pathway B2R influences the prostaglandin biosynthesis process. Its function in these pathways makes it important for the regulation of blood pressure and inflammatory reactions.

B2R has been implicated in conditions such as hypertension and hereditary angioedema. The receptor's role in hypertension is linked to its ability to mediate vasodilation and blood pressure regulation. In hereditary angioedema B2R is associated with excessive bradykinin activity leading to edema. Connections with proteins like kallikreins in these disorders highlight B2R's involvement in abnormal protein function that can result in clinical symptoms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
See full target information BDKRB2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of oncology 55:131-141 PubMed31059006

2019

Serum bradykinin levels as a diagnostic marker in cervical cancer with a potential mechanism to promote VEGF expression via BDKRB2.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Zhou,Wei Wang,Rui Wei,Guiying Jiang,Fei Li,Xi Chen,Xueqian Wang,Sixiang Long,Ding Ma,Ling Xi
View all publications
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