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AB236291

Anti-B3GNT1 antibody

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(2 Publications )

Rabbit Polyclonal B3GNT1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human B3GNT2 aa 1 to C-terminus.
1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B3GNT1 antibody (AB236291)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B3GNT1 antibody (AB236291)

Paraffin-embedded human skin tissue stained for B3GNT1 using ab236291 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human B3GNT2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NY97

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

B3GNT1 also known as UDP-GlcNAc:betaGal beta-13-N-acetylglucosaminyltransferase 1 is an enzyme that participates in glycosylation processes by transferring N-acetylglucosamine from UDP-GlcNAc to polylactosamine chains playing an important role in the synthesis of poly-N-acetyllactosamine. This protein has a mass of approximately 43 kDa and predominantly expresses in tissues that produce substantial amounts of glycosylated molecules such as the brain and the gastrointestinal tract.
Biological function summary

B3GNT1 contributes to the synthesis of glycan structures that are important for cell-cell interactions. It functions as an independent enzyme rather than as part of a larger enzymatic complex. The activity of B3GNT1 impacts the production of complex-type N- and O-glycans which support cellular adhesion signaling and immune recognition. Such functions make B3GNT1 significant in various physiological processes particularly in the development and maintenance of tissues.

Pathways

B3GNT1 is integral to the glycosaminoglycan biosynthesis and glycoprotein metabolic pathways. It interacts with other enzymes involved in these pathways such as beta-14-galactosyltransferase to construct poly-N-acetyllactosamine structures. The connectivity between B3GNT1 and other glycosyltransferases ensures proper assembly and function of glycan-containing molecules necessary for diverse biological activities.

Aberrant expression or malfunction of B3GNT1 links to conditions like congenital disorders of glycosylation and certain cancers. Abnormal glycosylation patterns sometimes involving related proteins such as FUT8 which is another glycosyltransferase can lead to defective cellular signaling and contribute to these pathologies. Understanding these connections helps in exploring therapeutic targets and diagnostic markers for glycosylation-related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed : 9892646). Probably constitutes the main polylactosamine synthase.
See full target information B3GNT2

Alternative Names

B3GALT7, B3GNT1, B3GNT2, Beta-3-Gx-T7, BGnT-1, Beta3Gn-T1, Beta3Gal-T7, Beta3GalT7, b3Gal-T7, BGnT-2, Beta3Gn-T2
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Publications (2)

Recent publications for all applications. Explore the full listand refine your search

Journal of dairy science 107:8722-8735 PubMed38876213

2024

Unveiling the regulatory role of SIRT1 in the oxidative stress response of bovine mammary cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yufei Zhang,Juxiong Liu,Shuai Yuan,Shu Liu,Meng Zhang,Huijie Hu,Yu Cao,Guiqiu Hu,Shoupeng Fu,Wenjin Guo

Cellular & molecular biology letters 27:8 PubMed35073841

2022

Construction and investigation of β3GNT2-associated regulatory network in esophageal carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiguo Luo,Qing Hu,Yuanhui Tang,Yahui Leng,Tian Tian,Shuangyue Tian,Chengyang Huang,Ao Liu,Xinzhou Deng,Li Shen
View all publications
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Product promise

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