JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB190217

Anti-B3GNT7 antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal B3GNT7 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human B3GNT7 aa 250-300 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

BGnT-7, Beta3Gn-T7, B3GNT7

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B3GNT7 antibody (AB190217)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B3GNT7 antibody (AB190217)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin tissue labeling B3GNT7 with ab190217 at 1/50 dilution.

Western blot - Anti-B3GNT7 antibody (AB190217)
  • WB

Supplier Data

Western blot - Anti-B3GNT7 antibody (AB190217)

All lanes:

Western blot - Anti-B3GNT7 antibody (ab190217) at 1/1000 dilution

All lanes:

Mouse heart lysate at 35 µg

Predicted band size: 46 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human B3GNT7 aa 250-300 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q8NFL0

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

B3GNT7 also known as β-13-N-acetylglucosaminyltransferase 7 is an enzyme involved in glycosylation processes. It has a mass of approximately 46 kDa. Found within the Golgi apparatus of cells B3GNT7 is responsible for catalyzing the transfer of N-acetylglucosamine (GlcNAc) residues to precursor oligosaccharides forming β1-3 glycosidic bonds. It shows widespread expression but levels are higher in tissues such as brain pancreas and kidneys indicating tissue-specific roles.
Biological function summary

B3GNT7 plays an important role in the biosynthesis of glycosaminoglycans which are complex polysaccharides. These polysaccharides provide structure and support to cells and tissues partaking in processes like cell signaling and maintaining cellular environment. B3GNT7 is not part of multienzyme complexes but interacts closely with other glycosylation enzymes. This specificity influences the structural diversity and function of glycosaminoglycans in various biological processes.

Pathways

B3GNT7 participates in the glycosaminoglycan biosynthesis pathway particularly in the synthesis of keratan sulfate. This pathway impacts cellular communication and structural integrity significant for tissue function. B3GNT7 functions alongside related enzymes such as B3GNT1 which also contribute to glycosaminoglycan chain elongation. The interactions with these enzymes play an important role in modifying glycosaminoglycan chains for distinct biological functions.

Alterations in B3GNT7 expression and function relate to osteoarthritis and certain neuropathies. In osteoarthritis abnormal glycosaminoglycan synthesis can lead to impaired joint function and cartilage deterioration. Interactions with proteins like B3GNT6 which has overlapping roles in glycosylation may influence disease progression. Understanding B3GNT7's impact on these conditions helps in developing targeted therapeutic strategies.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

N-acetyl glucosamine (GlcNAc) transferase that catalyzes the transfer of GlcNAc via a beta1->3 linkage from UDP-GlcNAc to the non-reducing terminal galactose (Gal) in the linearly growing chain of N- and O-linked keratan sulfate proteoglycans. Cooperates with B4GALT4 galactosyltransferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (PubMed : 14706853, PubMed : 17690104). Involved in biosynthesis of N-linked keratan sulfate proteoglycans in cornea, with an impact on proteoglycan fibril organization and corneal transparency (By similarity) (PubMed : 17690104). May play a role in the maintenance of tissue architecture by suppressing cellular motility and invasion (By similarity).
See full target information B3GNT7
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

BMC gastroenterology 24:202 PubMed38886669

2024

B3GNT7 regulates mucin O-glycosylation to alleviate colonic inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Tian Wang,Han Sun,Minna Zhang,Peng Shen,Yan Li

Metabolites 13: PubMed36676954

2022

Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner.

Applications

Unspecified application

Species

Unspecified reactive species

Alejandro Gutierrez Cruz,Mafalda S L Aresta Branco,Brian A Perrino,Kenton M Sanders,Violeta N Mutafova-Yambolieva
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB77995

Anti-MUC5B antibody [19.4E]

Immunohistochemistry (Frozen sections) - Anti-MUC5B antibody [19.4E] (AB77995)

  • 5
  • 2
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB237734

Anti-C1GALT1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1GALT1 antibody (AB237734)

  • 0
  • 0
Primary Antibodies

AB60720

Anti-MUC4 antibody [5B12]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MUC4 antibody [5B12] (AB60720)

  • 4
  • 2

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com