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AB234707

Anti-B4GALT2 antibody

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(1 Publication)

Rabbit Polyclonal B4GALT2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human B4GALT2 aa 250 to C-terminus.

View Alternative Names

Beta4Gal-T2, b4Gal-T2, Lactose synthase A protein, N-acetyllactosamine synthase, Nal synthase, B4GALT2

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human B4GALT2 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O60909

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

B4GALT2 also known as UDP-Gal:betaGlcNAc beta 14- galactosyltransferase polypeptide 2 is an enzyme involved in the glycosylation process. It has a molecular weight of about 41 kDa. You can find B4GALT2 in various tissues including liver kidney and heart. The enzyme transfers galactose to N-acetylglucosamine forming N-acetyllactosamine structures which are important in the synthesis of glycoproteins and glycolipids.
Biological function summary

The enzyme plays a role in critical cellular functions by participating in cell surface glycan formation. It is part of the galactosyltransferase family and works as a single polypeptide chain. B4GALT2 adds galactose residues in a beta 14 linkage on glycoproteins and glycolipids in the Golgi apparatus. This modification helps in cell communication and molecule stability.

Pathways

The B4GALT2 enzyme functions in the glycosylation pathway especially in the N-linked glycosylation process. It interacts with other enzymes like B4GALT1 and B4GALT3 involved in the same pathway. Both perform similar roles but work on different substrates or in different contexts in the cell contributing to the diversity of glycan structures seen in organisms.

B4GALT2 influences cancer progression and congenital disorders of glycosylation. Altered expression or function of B4GALT2 has been associated with tumor metastasis and progression particularly in breast cancer. Additionally mutations in B4GALT2 can lead to congenital disorders affecting glycoprotein modification and function. The protein interacts with other enzymes such as GALNTs in these disease contexts influencing their pathology and outcomes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids (PubMed : 9405390). Can produce lactose (PubMed : 9405390).
See full target information B4GALT2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 40:111086 PubMed35858576

2022

Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related proteins in the nucleus.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Gao,Jinge Gu,Hong Zhang,Kai Jiang,Linlin Tang,Ren Liu,Li Zhang,Pengfei Zhang,Cong Liu,Bin Dai,Jie Song
View all publications
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Product promise

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