Anti-BAAT antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

BAAT also known as Bile Acid-CoA: Amino Acid N-Acyltransferase is an enzyme that catalyzes the transfer of amino acids to bile acids forming conjugated bile acids. This process increases bile acid solubility and facilitates its function. BAAT has a molecular mass of approximately 47 kDa and is highly expressed in the liver. This expression is central for the enzyme's role in facilitating bile acid processing which is critical in fat digestion and absorption.

Biological function summary

BAAT plays an important role in conjugating bile acids with amino acids such as glycine and taurine. This conjugation modifies the hydrophobicity and toxicity of bile acids making them more water-soluble. BAAT operates within the mitochondria and functions as an independent enzyme rather than being part of a larger enzymatic complex. Its essential role lies in maintaining the homeostasis of bile acids which is important for lipid metabolism.

Pathways

BAAT is a part of the bile acid biosynthesis pathway. It assists in the conversion process that ensures the enterohepatic circulation of bile acids. Within this pathway BAAT works closely with enzymes like the cytochrome P450 family especially CYP7A1 which initiate bile acid synthesis. This partnership maintains the cycle of conversion and reabsorption of bile acids ensuring their availability for dietary fat processing.

Associated diseases and disorders

BAAT relates significantly to disorders affecting bile acid metabolism such as cholestasis and gallstones. Abnormalities or deficiencies in BAAT activity can disrupt bile acid homeostasis contributing to these conditions. Moreover BAAT dysfunction is closely associated with defects in CYP7A1 as both enzymes play interconnected roles in bile acid synthesis and regulation. Understanding these interactions can provide insights into therapeutic approaches for bile-related disorders.