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AB220859

Anti-BarX1 antibody

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(2 Publications )

Rabbit Polyclonal BARX1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Homeobox protein BarH-like 1 aa 200-300.

View Alternative Names

Homeobox protein BarH-like 1, BARX1

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-BarX1 antibody (AB220859)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-BarX1 antibody (AB220859)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized A549 cells labeling BarX1 with ab220859 at 4 μg/ml (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human Homeobox protein BarH-like 1 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.

Q9HBU1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

BarX1 also known as BarH-like homeobox 1 is a transcription factor with a molecular mass of approximately 29 kDa. It is part of the Bar family of proteins which play essential roles in development. BarX1's primary expression occurs in the central nervous system and mesenchymal tissues during embryonic development. In adults BarX1 shows limited expression in specific tissues such as the stomach where it may serve various regulatory functions.
Biological function summary

BarX1 functions in the development of multiple organ systems particularly in teeth and stomach. It acts by influencing the differentiation and proliferation of cells during the formation of these structures. BarX1 is known to be part of a regulatory complex that controls the expression of genes critical for morphogenesis and tissue specification. Its interaction with other homeobox proteins further expands its impact on development.

Pathways

BarX1 interacts in key developmental signaling pathways such as Wnt and Hedgehog. These pathways play significant roles in development influencing cell fate and patterning. BarX1's interaction with proteins like beta-Catenin in the Wnt pathway helps modulate the activity of downstream genes necessary for development. By participating in these pathways BarX1 helps maintain the balance between cell proliferation and differentiation.

Dysregulation of BarX1 expression has been linked to conditions such as gastric cancer and tooth agenesis. In gastric cancer abnormal BarX1 levels can disrupt normal gene expression leading to uncontrolled cell growth and tumor development. Connections also exist between BarX1 and E-cadherin; alterations in this interaction can influence cancer progression. In tooth agenesis insufficient BarX1 activity can impair the formation of dental tissues resulting in missing teeth. Understanding these associations aids in developing targeted therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity (By similarity). Binds to a regulatory module of the NCAM promoter.
See full target information Homeobox protein BarH-like 1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Oncology reports 52: PubMed39450540

2024

HOXD1 inhibits lung adenocarcinoma progression and is regulated by DNA methylation.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Hu,Sijia Zhang,Xiaoyu Zhang,Hongyan Liu,Yutao Diao,Lianlian Li

Journal of orthopaedic surgery and research 18:211 PubMed36927457

2023

BARX1 promotes osteosarcoma cell proliferation and invasion by regulating HSPA6 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Xing Huang,Zhenhua Wang,Jing Zhang,Xiangzhi Ni,Guangjian Bai,Jiashi Cao,Chunlei Zhang,Zhitao Han,Tielong Liu
View all publications
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Product promise

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