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AB20128

Anti-BarX2 antibody [BAR X2 8A7/1]

4

(1 Review)

|

(2 Publications)

Mouse Monoclonal BARX2 antibody. Suitable for ELISA, WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Protein within Human BARX2.

View Alternative Names

Homeobox protein BarH-like 2, BARX2

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

BAR X2 8A7/1

Isotype

IgG1

Light chain type

unknown

Carrier free

No

Reacts with

Human

Applications

ELISA, IHC-P, ICC/IF, WB

applications

Immunogen

Recombinant Protein within Human BARX2. The exact immunogen used to generate this antibody is proprietary information.

Q9UMQ3

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Reactivity data

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Product details

BarX2 is a tumour suppressor gene that encodes for a transcription factor known to regulate transcription of cell adhesion molecules in the mouse.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

BarX2 also known as BarH-like 2 is a transcription factor involved in gene regulation. BarX2 has an estimated mass of around 36 kDa. It initially expresses in various tissues including the central nervous system and the developing limb. BarX2 contains a homeobox domain a DNA-binding region influencing gene expression by interacting with specific DNA sequences. This capability makes it critical in transcriptional regulation involved in developmental processes.
Biological function summary

BarX2 plays a significant role in neuronal differentiation and limb patterning. It functions by controlling the expression of downstream target genes that drive cellular differentiation and growth. BarX2 does not form part of a larger complex but interacts individually with target genes in developmentally active tissues. It affects the expression patterns that lead to specific cell fates especially during embryogenesis.

Pathways

The transcription factor BarX2 integrates into critical pathways like the Wnt signaling and Notch signaling. These pathways are pivotal in regulating cell proliferation differentiation and apoptosis. BarX2 works alongside proteins like beta-catenin in Wnt signaling to influence gene expression changes important for cell fate decisions. In Notch signaling BarX2 modulates the balance between cell proliferation and differentiation essential in developing organs.

BarX2 has connections to oncogenesis and certain developmental defects. Its altered expression or mutation correlates with colorectal cancer impacting the regulation of cell proliferation and apoptosis. BarX2 interacts with proteins such as c-Myc which plays a role in promoting cellular growth and cancer development. Additionally in developmental defects aberrant BarX2 expression links to limb malformations where it influences the expression of genes controlling limb patterning and skeletal formation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity).
See full target information BARX2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:11974 PubMed40199990

2025

Menstrual blood serum extracellular vesicles reveal novel molecular biomarkers and potential endotypes of unexplained infertility.

Applications

Unspecified application

Species

Unspecified reactive species

Kieran Brennan,Raminta Vaiciuleviciute,Ilona Uzieliene,Jolita Pachaleva,Zaneta Kasilovskiene,Lina Piesiniene,Eiva Bernotiene,Margaret M Mc Gee

Journal of cellular physiology 234:23596-23607 PubMed31236953

2019

miR-942 promotes tumor migration, invasion, and angiogenesis by regulating EMT via BARX2 in non-small-cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Fengming Yang,Chuchu Shao,Ke Wei,Xinming Jing,Zhiqiang Qin,Yuenian Shi,Yongqian Shu,Hua Shen
View all publications
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Product promise

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