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AB14373

Anti-Basal Bodies of Cillia antibody [LhS28]

3

(1 Review)

|

(7 Publications)

Mouse Monoclonal Human Basal Bodies of Cillia antibody. Suitable for IHC-P, IHC-Fr, IP and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Cell preparation containing Human Basal Bodies of Cillia protein.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

LhS28

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P, IHC-Fr, IP

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

This antibody recognises the basal bodies of cillia in all cilliated cells.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Basal bodies are structural organelles that serve as the microtubule-organizing centers of cilia and flagella. Also known as basal granules or kinetosomes basal bodies form the base from which the axoneme of the cilia or flagella extends. They possess a cylindrical shape composed of nine triplet microtubules arranged akin to centrioles and typically share a similar molecular mass. These structures are expressed ubiquitously in ciliated cells across various tissues such as the respiratory epithelium and the ventricular ependyma highlighting their ubiquitous presence in multicellular organisms.
Biological function summary

Basal bodies function as critical regulators of cilia formation and maintenance. They play an essential role in positioning and anchoring cilia to the cell surface ensuring proper orientation. Basal bodies are a component of a larger ciliary complex that includes proteins such as dynein arms and the ciliary membrane. These complexes participate in selective protein trafficking facilitating the growth and function of cilia by transporting necessary molecular components.

Pathways

Basal bodies interface with important cellular signaling pathways including the Hedgehog and Wnt pathways. These pathways are important for cell differentiation and developmental processes. Basal bodies interact with proteins such as Gli in the Hedgehog pathway and Dishevelled in the Wnt pathway regulating signal transduction mechanisms critical to maintaining cellular homeostasis.

Basal bodies relate closely to ciliopathic conditions like Primary Ciliary Dyskinesia and Polycystic Kidney Disease. These disorders often arise due to defects in cilia formation and function linked to basal body malfunction. The dysfunction in basal bodies can affect proteins like dynein leading to impaired ciliary motility in disorders such as Primary Ciliary Dyskinesia or defects in cyst formation in Polycystic Kidney Disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Human Basal Bodies of Cillia
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

American journal of physiology. Lung cellular and molecular physiology 318:L1063-L1073 PubMed32208929

2020

Structural and functional variations in human bronchial epithelial cells cultured in air-liquid interface using different growth media.

Applications

Unspecified application

Species

Unspecified reactive species

Clarus Leung,Samuel J Wadsworth,S Jasemine Yang,Delbert R Dorscheid

Nature protocols 10:363-81 PubMed25654755

2015

Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Amy P Wong,Stephanie Chin,Sunny Xia,Jodi Garner,Christine E Bear,Janet Rossant

Fertility and sterility 99:199-205 PubMed23009827

2012

Effect of cigarette smoking on human oviductal ciliation and ciliogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Bruce Pier,Avedis Kazanjian,Laurie Gillette,Karen Strenge,Richard O Burney

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 30:12-21 PubMed21131839

2010

The origin of ovarian carcinomas: a unifying hypothesis.

Applications

IHC-P

Species

Human

Nelly Auersperg

Journal of clinical pathology 52:355-7 PubMed10560355

1999

Application of a marker of ciliated epithelial cells to gynaecological pathology.

Applications

Unspecified application

Species

Unspecified reactive species

M T Comer,A C Andrew,H J Leese,L K Trejdosiewicz,J Southgate

The Histochemical journal 31:39-43 PubMed10405821

1999

Expression of an antigen associated with basal bodies of human ciliated epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

M T Comer,M Shires,N P Goode,H J Leese,L K Trejdosiewicz,J Southgate

Human reproduction (Oxford, England) 13:3114-20 PubMed9853867

1998

Induction of a differentiated ciliated cell phenotype in primary cultures of Fallopian tube epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

M T Comer,H J Leese,J Southgate
View all publications
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Product promise

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