Anti-Bcl-2 antibody [BCL2/2210R]
- Recombinant
- What is this?
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(4 Publications)
Rabbit Recombinant Monoclonal Bcl-2 antibody. Suitable for WB, Protein Array, IHC-P and reacts with Human, Recombinant full length protein - Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human BCL2.
View Alternative Names
Apoptosis regulator Bcl-2, BCL2
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bcl-2 antibody [BCL2/2210R] (AB238041)
Formalin-fixed, paraffin-embedded human spleen tissue stained for Bcl-2 using ab238041 at 1 μg/ml in immunohistochemical analysis.
- Protein Array
Unknown
Protein Array - Anti-Bcl-2 antibody [BCL2/2210R] (AB238041)
ab238041 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
- WB
Supplier Data
Western blot - Anti-Bcl-2 antibody [BCL2/2210R] (AB238041)
All lanes:
Western blot - Anti-Bcl-2 antibody [BCL2/2210R] (ab238041) at 1 µg/mL
All lanes:
MCF7 (human breast adenocarcinoma cell line) cell lysate
Predicted band size: 26 kDa
false
Reactivity data
Product details
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Properties and storage information
Form
Purification technique
Purification notes
Storage buffer
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The role of Bcl-2 extends to maintaining cell survival and balancing apoptotic signals. It functions as an anti-apoptotic molecule within the cell primarily involved in forming complexes with pro-apoptotic members of the Bcl-2 family like Bax and Bak. These interactions prevent mitochondrial membrane permeabilization which is an important step in apoptotic signal transduction. As an important regulator of apoptosis Bcl-2 helps in cellular homeostasis and appropriate immune responses under physiological conditions.
Pathways
Bcl-2 plays a critical role in the intrinsic or mitochondrial pathway of apoptosis. Within this pathway Bcl-2 interacts with other proteins such as cytochrome c and APAF-1 to inhibit apoptosis. This pathway involves a network of Bcl-2 family proteins where Bcl-2's anti-apoptotic role counteracts the pro-apoptotic activity of proteins like Bax. These interactions help fine-tune the apoptotic response to various internal stimuli maintaining cellular integrity and function.
Product protocols
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Target data
Publications (4)
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The journal of gene medicine 25:e3507 PubMed36999202
2023
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Molecular and cellular biology 41:e0006521 PubMed34001648
2021
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Open life sciences 16:495-510 PubMed34056113
2021
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Artificial cells, nanomedicine, and biotechnology 47:2265-2273 PubMed31184221
2019
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Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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