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AB108328

Anti-Bcl10 antibody [EPR3175]

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(3 Publications)

Rabbit Recombinant Monoclonal BCL10 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications.

View Alternative Names

CIPER, CLAP, BCL10, B-cell lymphoma/leukemia 10, B-cell CLL/lymphoma 10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, CED-3/ICH-1 prodomain homologous E10-like regulator, Cellular homolog of vCARMEN, Cellular-E10, Mammalian CARD-containing adapter molecule E10, Bcl-10, hCLAP, cCARMEN, c-E10, mE10

2 Images
Western blot - Anti-Bcl10 antibody [EPR3175] (AB108328)
  • WB

Unknown

Western blot - Anti-Bcl10 antibody [EPR3175] (AB108328)

All lanes:

Western blot - Anti-Bcl10 antibody [EPR3175] (ab108328) at 1/1000 dilution

Lane 1:

Daudi cell lysate at 10 µg

Lane 2:

Raji cell lysate at 10 µg

Lane 3:

HeLa cell lysate at 10 µg

Lane 4:

HuT-78 cell lysate at 10 µg

Predicted band size: 26 kDa

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Immunocytochemistry/ Immunofluorescence - Anti-Bcl10 antibody [EPR3175] (AB108328)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Bcl10 antibody [EPR3175] (AB108328)

ab108328, at 1/100 dilution, staining Bcl10 in HeLa cells by Immunofluorescence.

  • Carrier free

    Anti-Bcl10 antibody [EPR3175] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR3175

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Bcl10 also known as B-cell lymphoma 10 is a protein involved in several cellular processes. It has a molecular mass of approximately 26 kDa and shows expression in various lymphoid tissues. Bcl10 plays a significant role in signaling pathways by transmitting signals from the cell surface to the nucleus impacting cell growth and immune responses. Researchers often study Bcl10 using immunohistochemistry (IHC) techniques referred to as Bcl10 IHC to analyze its expression and distribution within tissues.
Biological function summary

Bcl10 activates downstream signaling pathways that are critical for immune cell functioning and survival. It forms part of the CARD-BCL10-MALT1 (CBM) complex which is important for the activation of the NF-kB pathway. This complex formation is essential for lymphocyte activation and proliferation. Bcl10 interactions within this complex influence cellular responses to various stimuli helping organisms to mount appropriate immune responses.

Pathways

Bcl10 serves as an integral component in the NF-kB and TCR signaling pathways. It functions alongside proteins such as MALT1 and CARD9 in these pathways. The proper functioning of Bcl10 in these pathways ensures accurate transcriptional regulation necessary for immune responses. Misregulation in these pathways can lead to immune disorders and aberrant cell behavior linking Bcl10 to further biological implications.

Bcl10 shows associations with mucosa-associated lymphoid tissue (MALT) lymphoma and other inflammatory diseases. Aberrant Bcl10 expression or mutations can lead to unchecked activation of NF-kB contributing to the progression of these conditions. In MALT lymphoma Bcl10 often cooperates with MALT1 both contributing to pathological cell survival and proliferation highlighting the importance of Bcl10 in understanding these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed : 10187770, PubMed : 10364242, PubMed : 10400625, PubMed : 24074955, PubMed : 25365219). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed : 24074955). Recruited by activated CARD domain-containing proteins : homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed : 24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed : 18287044, PubMed : 24074955, PubMed : 27777308). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed : 26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed : 18264101, PubMed : 18287044, PubMed : 24074955, PubMed : 27777308). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed : 10187815).
See full target information BCL10
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 12:786572 PubMed34868072

2021

Clinical and Immunological Features of Human BCL10 Deficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Blanca Garcia-Solis,Ana Van Den Rym,Jareb J Pérez-Caraballo,Abdulwahab Al-Ayoubi,Anas M Alazami,Lazaro Lorenzo,Carolina Cubillos-Zapata,Eduardo López-Collazo,Antonio Pérez-Martínez,Luis M Allende,Janet Markle,Miguel Fernández-Arquero,Silvia Sánchez-Ramón,Maria J Recio,Jean-Laurent Casanova,Reem Mohammed,Rubén Martinez-Barricarte,Rebeca Pérez de Diego

Annals of translational medicine 7:758 PubMed32042774

2020

Upregulated inhibits inflammatory response induced by in human monocytes derived dendritic cells via targeting p65 and BCL-10.

Applications

Unspecified application

Species

Unspecified reactive species

Ting-Ting Wei,Zhuo Cheng,Zhi-De Hu,Lin Zhou,Ren-Qian Zhong

The Journal of clinical investigation 124:5239-48 PubMed25365219

2014

Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Manuel Torres,Rubén Martinez-Barricarte,Sonia García-Gómez,Marina S Mazariegos,Yuval Itan,Bertrand Boisson,Rita Rholvarez,Anaïs Jiménez-Reinoso,Lucia del Pino,Rebeca Rodríguez-Pena,Antonio Ferreira,Enrique Hernández-Jiménez,Victor Toledano,Carolina Cubillos-Zapata,Mariana Díaz-Almirón,Eduardo López-Collazo,José L Unzueta-Roch,Silvia Sánchez-Ramón,Jose R Regueiro,Eduardo López-Granados,Jean-Laurent Casanova,Rebeca Pérez de Diego
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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