Anti-Bcl2 alpha antibody [SP66] - N-terminal

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Bcl2 alpha controls the intrinsic pathway of apoptosis. It is a part of the Bcl-2 family which consists of proteins that either promote or inhibit apoptosis. Bcl2 alpha interacts with other Bcl-2 family members forming either pro-apoptotic or anti-apoptotic complexes. It ensures cell survival by preventing the release of cytochrome c from mitochondria and interacting with pro-apoptotic proteins like Bax and Bak. This interaction obstructs the activation of caspase enzymes which are critical in the execution of apoptosis.

Pathways

Bcl2 alpha functions within the apoptotic and mitochondrial pathways. In the apoptotic pathway Bcl2 alpha plays an anti-apoptotic role by modulating the activity of pro-apoptotic proteins mainly through its interactions with Bax and Bak. Within the mitochondrial pathway Bcl2 alpha affects the permeability of the mitochondrial membrane thereby influencing the release of factors that initiate caspase activation. These pathways involve interconnected roles with other key proteins these roles affecting processes such as cell cycle regulation and response to cellular stress.