Anti-Bcl2-L-13 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Bcl2-L-13 regulates mitochondrial dynamics and influences the mitochondrial apoptotic machinery. It can act as a pro-apoptotic or anti-apoptotic factor depending on its interactions with other Bcl-2 family proteins. This protein does not work alone but often forms complexes with other Bcl-2 family members to modulate apoptotic pathways. By affecting mitochondrial membrane permeabilization it controls the release of cytochrome c and other pro-apoptotic factors that trigger downstream caspase cascades.

Pathways

Bcl2-L-13 is involved in intrinsic apoptosis signaling and mitochondrial maintenance pathways. It interacts with proteins like Bax and Bak facilitating either protection against apoptosis or promotion of cell death. Additionally Bcl2-L-13 influences crosstalk between the mitochondria and other cellular organelles affecting cell survival and death mechanisms under stress conditions. These interactions play a significant role in maintaining cellular homeostasis.