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AB77189

Anti-beta 1 Adrenergic Receptor antibody

4

(3 Reviews)

|

(9 Publications)

Goat Polyclonal beta 1 Adrenergic Receptor antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human ADRB1.

View Alternative Names

ADRB1R, B1AR, ADRB1, Beta-1 adrenergic receptor, Beta-1 adrenoreceptor, Beta-1 adrenoceptor

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta 1 Adrenergic Receptor antibody (AB77189)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta 1 Adrenergic Receptor antibody (AB77189)

Immmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human heart tissue labelling beta 1 Adrenergic Receptor with ab77189 at 6 µg/mL. Heat mediated antigen retrieval was performed with citrate buffer pH 6. HRP-staining.

Immunocytochemistry/ Immunofluorescence - Anti-beta 1 Adrenergic Receptor antibody (AB77189)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-beta 1 Adrenergic Receptor antibody (AB77189)

Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing membrane and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control : Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Synthetic Peptide within Human ADRB1. The exact immunogen used to generate this antibody is proprietary information.

P08588

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Complementary Products

Primary Antibodies

AB182136

Anti-beta 2 Adrenergic Receptor antibody [EPR707(N)]

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Immunohistochemistry (Frozen sections) - Anti-beta 2 Adrenergic Receptor antibody [EPR707(N)] (AB182136)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB94506

Anti-beta 3 Adrenergic Receptor antibody

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Western blot - Anti-beta 3 Adrenergic Receptor antibody (AB94506)

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Primary Antibodies

AB8227

Anti-beta Actin antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Western blot - Anti-beta Actin antibody - Loading Control (AB8227)

  • 5
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "6 µg/mL", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Gerbil": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Guinea pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rhesus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The beta 1 adrenergic receptor also known as beta-1 adrenoceptor or beta-1 receptor is a G protein-coupled receptor involved in the response to epinephrine and norepinephrine. It has a molecular mass of approximately 51 kDa. This receptor is mainly expressed in the heart where it plays a significant role in regulating cardiovascular functions. It is also found in other tissues like the brain and kidneys though at lower levels. The beta-1 adrenergic receptor functions by activating adenylate cyclase which increases intracellular cAMP levels.
Biological function summary

The beta 1 adrenergic receptor influences heart rate and cardiac contractility. This receptor is key in the sympathetic nervous system affecting physiological responses during stress or exercise. It does not form part of a complex in its active state. Upon activation the receptor enhances cardiac output by increasing the force and frequency of heart contractions. It also contributes to the relaxation of vascular and smooth muscle tissues facilitating better blood flow and pressure regulation.

Pathways

Beta 1 adrenergic receptor is integral to the adrenergic signaling pathway. It works alongside proteins like adenylate cyclase to modulate the levels of cAMP within the cell which acts as a secondary messenger in signal transduction. The receptor plays a significant role in the fight-or-flight response coordinating with other adrenergic receptors like the beta 2 adrenergic receptor to ensure a well-rounded physiological reaction to stressors. Another pathway of significance is the cardiac beta-adrenergic signaling which involves the regulation of heart muscle activities.

The beta 1 adrenergic receptor is associated with heart failure and hypertension. In heart failure altered expression or function of this receptor can lead to impaired contractile response and cardiac performance. In hypertension overactive adrenergic receptor signaling contributes to increased cardiac output and blood pressure. Related proteins include the beta-2 adrenergic receptor and angiotensin II which can exacerbate these conditions when dysregulated influencing the development and progression of cardiovascular diseases. Esmolol a beta-1 selective blocker is often used to manage these conditions by targeting the receptor specifically to reduce heart rate and blood pressure.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway (PubMed : 10212248, PubMed : 12391161, PubMed : 15358775). Binds epinephrine and norepinephrine with approximately equal affinity (PubMed : 33093660). Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2 (PubMed : 12391161). As part of the sympathetic nervous system, plays a role in the physiologic regulation of cardiac functions such as stimulation of cardiomyocyte contraction (PubMed : 11052857). Also delivers proapoptotic signals in cardiomyocytes (By similarity). Involved in the regulation of sleep/wake behaviors (PubMed : 11854867, PubMed : 31473062).
See full target information ADRB1
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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in physiology 13:805909 PubMed35514336

2022

Aging Alters the Formation and Functionality of Signaling Microdomains Between L-type Calcium Channels and β2-Adrenergic Receptors in Cardiac Pacemaker Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Sabrina Choi,Oscar Vivas,Matthias Baudot,Claudia M Moreno

Medical science monitor : international medical jo 26:e922277 PubMed32447339

2020

Tragus Nerve Stimulation Suppresses Post-Infarction Ventricular Arrhythmia by Modulating Autonomic Activity and Heterogeneities of Cardiac Receptor Distribution.

Applications

Unspecified application

Species

Unspecified reactive species

Huaxin Sun,Buajieer-Guli Nasi-Er,Xuesheng Wang,Ling Zhang,Yanmei Lu,Xianhui Zhou,Yaodong Li,Lianwei Dong,Qina Zhou,BaoPeng Tang

The journals of gerontology. Series A, Biological sciences and medical sciences 75:1473-1480 PubMed31956900

2020

Aging Blunts Sympathetic Neuron Regulation of Motoneurons Synaptic Vesicle Release Mediated by β1- and α2B-Adrenergic Receptors in Geriatric Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Zhong-Min Wang,Anna Carolina Zaia Rodrigues,María Laura Messi,Osvaldo Delbono

Experimental physiology 103:1221-1229 PubMed29928790

2018

Targeted ablation of cardiac sympathetic neurons attenuates adverse postinfarction remodelling and left ventricular dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Liang Xiong,Yu Liu,Mingmin Zhou,Guangji Wang,Dajun Quan,Wei Shuai,Caijie Shen,Bin Kong,Congxin Huang,He Huang

Journal of cellular physiology 230:356-65 PubMed24986762

2014

Beta-Adrenoceptor Activation Reduces Both Dermal Microvascular Endothelial Cell Migration via a cAMP-Dependent Mechanism and Wound Angiogenesis.

Applications

WB

Species

Human

Andrew P O'Leary,James M Fox,Christine E Pullar

Journal of paediatrics and child health 50:619-25 PubMed24905852

2014

Infantile haemangiomas that failed treatment with propranolol: clinical and histopathological features.

Applications

Unspecified application

Species

Unspecified reactive species

Roderic J Phillips,Zerina Lokmic,Catherine M Crock,Anthony Penington

Adipocyte 1:132-181 PubMed23700522

2013

Differentiation of human adipocytes at physiological oxygen levels results in increased adiponectin secretion and isoproterenol-stimulated lipolysis.

Applications

Unspecified application

Species

Human

Susanne Famulla,Raphaela Schlich,Henrike Sell,Jürgen Eckel

Carcinogenesis 33:191-6 PubMed22072614

2011

Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention.

Applications

WB

Species

Human

Hildegard M Schuller,Hussein A N Al-Wadei,Mohammad F Ullah,Howard K Plummer

Journal of the American College of Cardiology 55:463-8 PubMed20117461

2010

Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patients.

Applications

Unspecified application

Species

Rat

Gerd Wallukat,Silvia Gilka Muñoz Saravia,Annekathrin Haberland,Sabine Bartel,Raul Araujo,Gregorio Valda,Diana Duchen,Ivan Diaz Ramirez,Adrian Constantin Borges,Ingolf Schimke
View all publications
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Product promise

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