Rabbit Polyclonal beta 2 Adrenergic Receptor phospho S346 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ADRB2 phospho S346 conjugated to Keyhole Limpet Haemocyanin.
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- Human mutation 42:1279-12932021Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conduction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaen D Abou Ziki,Neha Bhat,Arpita Neogi,Tristan P Driscoll,Nelson Ugwu,Ya Liu,Emily Smith,Johny M Abboud,Salah Chouairi,Martin A Schwartz,Joseph G Akar,Arya ManiPubMed 34289528
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human ADRB2 phospho S346 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link P07550
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/1000 | Notes - |
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3 products for Alternative Product
Target data
Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Alternative names
ADRB2R, B2AR, ADRB2, Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, Beta-2 adrenoceptor
Recommended products
Rabbit Polyclonal beta 2 Adrenergic Receptor phospho S346 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ADRB2 phospho S346 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human ADRB2 phospho S346 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link P07550
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
ab192821 was purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The beta 2 adrenergic receptor (also known as beta-2 adrenergic receptor B2 adrenergic receptor beta-2 receptor) is a transmembrane protein that acts as a receptor for catecholamines like adrenaline and noradrenaline. It belongs to the G protein-coupled receptors (GPCRs) superfamily and is involved in signal transduction by activating adenylate cyclase through the Gs protein. The mass of the beta 2 adrenergic receptor is approximately 46 kDa. This receptor is expressed in various tissues including the lungs skeletal muscle liver and smooth muscle.
- Biological function summary
The beta 2 adrenergic receptor is important for mediating the physiological responses to adrenaline and noradrenaline. It plays a significant role in bronchodilation and vasodilation by relaxing airway and vascular smooth muscles. While it does not form a part of any complex its signaling initiates a cascade of intracellular events leading to changes in cellular function. This receptor ensures tissue responsiveness to catecholamines influencing cardiac output metabolic rate and smooth muscle relaxation.
- Pathways
This receptor is an important component of the adrenergic signaling pathway and is closely associated with the cAMP-dependent signaling pathway. The activation of the beta 2 adrenergic receptor increases intracellular cAMP levels resulting in the activation of protein kinase A (PKA) and subsequent phosphorylation of various target proteins. The receptor interacts with other proteins within these pathways such as adenylate cyclase and PKA ensuring the propagation of downstream signaling that modulates cellular responses.
- Associated diseases and disorders
The beta 2 adrenergic receptor has a notable connection to asthma and chronic obstructive pulmonary disease (COPD). Its role in bronchodilation makes it a therapeutic target for managing these respiratory conditions. Alterations in the function or expression of the beta 2 adrenergic receptor can exacerbate these diseases. Additionally these disorders demonstrate a link with the muscarinic acetylcholine receptors which also affect airway tone regulation. Understanding the interactions between these receptors is essential for developing therapeutic strategies for respiratory diseases.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-beta 2 Adrenergic Receptor (phospho S346) antibody (ab192821)
HepG2 cell extracts treated with Nocodazole
All lanes: Western blot - Anti-beta 2 Adrenergic Receptor (phospho S346) antibody (ab192821) at 1/500 dilution
Lane 1: HepG2 cell extracts treated with Nocodazole - no peptide
Lane 2: HepG2 cell extracts treated with Nocodazole.- with the antigen-specific peptide
Predicted band size: 46 kDa
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