AB76249

Anti-beta 3 Adrenergic Receptor antibody

Name: Anti-beta 3 Adrenergic Receptor antibody (ab76249) | Abcam
Brand: Abcam Limited
SKU: AB76249
Price: 535 USD
Availability: InStock

(1 Review)

(7 Publications)

Rabbit Polyclonal beta 3 Adrenergic Receptor antibody. Suitable for WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human ADRB3.

View Alternative Names

ADRB3R, B3AR, ADRB3, Beta-3 adrenergic receptor, Beta-3 adrenoreceptor, Beta-3 adrenoceptor

1 Images

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Western blot - Anti-beta 3 Adrenergic Receptor antibody (AB76249)

All lanes:

Western blot - Anti-beta 3 Adrenergic Receptor antibody (ab76249) at 1/500 dilution

Lane 1:

Extracts from K562 cells at 5 µg

Lane 2:

Extracts from K562 cells at 5 µg with immunising peptide

Predicted band size: 44 kDa

Observed band size: 35 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human ADRB3. The exact immunogen used to generate this antibody is proprietary information.

P13945

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The beta 3 adrenergic receptor also known as beta-3 adrenoceptor or B3 adrenergic receptor is a member of the adrenergic receptor family that activates the GS protein upon binding ligands like catecholamines. This receptor approximately 408 amino acids in size has a predominant mass of around 45 kDa. It is mainly expressed in adipose tissue but also found in the gallbladder urinary bladder and the gastrointestinal tract. These receptors primarily mediate lipolysis and thermogenesis in brown adipose tissue through interaction with norepinephrine and epinephrine.

Biological function summary

The beta 3 adrenergic receptor plays an important role in energy expenditure and metabolic processes. It does not typically form part of a complex but interacts with GS proteins leading to the activation of adenylyl cyclase and consequent increase in cAMP levels. This receptor is instrumental in the regulation of lipid metabolism which aids in maintaining balance in energy store.

Pathways

The beta 3 adrenergic receptor is involved in the adrenergic signaling pathways regulating energy expenditure and thermogenesis. These pathways often work together with other adrenergic receptors such as beta 1 and beta 2 receptors. An important pathway involving the beta 3 adrenergic receptor is the cAMP-dependent pathway which influences metabolic functions and energy homeostasis in the body.

The beta 3 adrenergic receptor is associated with obesity and diabetes. Altered function or expression of this receptor can impact the body's ability to regulate energy metabolism leading to these metabolic disorders. The receptor's function has connections with insulin-like growth factor 1 (IGF1) as changes in energy metabolism affect insulin signaling and glucose homeostasis. Abnormal adrenergic receptor activity can also contribute to bladder disorders due to its expression in the urinary system.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

See full target information ADRB3

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Physiological reports 11:e15549 PubMed36597221

2023

β3 adrenergic agonism: A novel pathway which improves right ventricular-pulmonary arterial hemodynamics in pulmonary arterial hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Keyvan Karimi Galougahi,Yunjia Zhang,Vivian Kienzle,Chia-Chi Liu,Lake-Ee Quek,Sanjay Patel,Edmund Lau,Rachael L Cordina,Gemma A Figtree,David S Celermajer

The Journal of nutritional biochemistry 85:108480 PubMed32795655

2020

Sex hormone-binding globulin overexpression protects against high-fat diet-induced obesity in transgenic male mice.

Applications

Unspecified application

Species

Unspecified reactive species

Cristina Saez-Lopez,Josep A Villena,Rafael Simó,David M Selva

Neurourology and urodynamics 39:1292-1303 PubMed32330364

2020

β-Adrenoceptors regulate matrix metalloproteinase expression in human urothelial cells under hydrostatic pressure.

Applications

Unspecified application

Species

Unspecified reactive species

Jianhua Lan,Tao Jin,Jianzhong Ai,Xin Wei,Zhihui Huang,Hua Chen,Xi Jin,Zhumei Luo,Kunjie Wang

Journal of cellular biochemistry 120:17872-17886 PubMed31161623

2019

β-Adrenoceptor signaling regulates proliferation and contraction of human bladder smooth muscle cells under pathological hydrostatic pressure.

Applications

Unspecified application

Species

Unspecified reactive species

Junyu Lai,Jianzhong Ai,Deyi Luo,Tao Jin,Banghua Liao,Liang Zhou,Shijian Feng,Xi Jin,Hong Li,Kunjie Wang

Biochemical and biophysical research communication 514:295-300 PubMed31030945

2019

Targeting β3-adrenergic receptor signaling inhibits neuroblastoma cell growth via suppressing the mTOR pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Deng,Ping Jiang,Tianyou Yang,Mao Huang,Weiwei Qi,Ti Zhou,Zhonghan Yang,Yan Zou,Guoquan Gao,Xia Yang

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 38:514-30 PubMed26828873

2016

The β3 Adrenergic Receptor Agonist BRL37344 Exacerbates Atrial Structural Remodeling Through iNOS Uncoupling in Canine Models of Atrial Fibrillation.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaobing Wang,Ruifeng Wang,Guangzhong Liu,Jingmei Dong,Guanqi Zhao,Jingpu Tian,Jiayu Sun,Xiuyue Jia,Lin Wei,Yuping Wang,Weimin Li

Modern pathology : an official journal of the Unit 25:1446-51 PubMed22743651

2012

β-Adrenergic receptor expression in vascular tumors.

Applications

IHC-P

Species

Human

Karen M Chisholm,Kay W Chang,Mai T Truong,Shirley Kwok,Rob B West,Amy E Heerema-McKenney

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-beta 3 Adrenergic Receptor antibody

Western blot - Anti-beta 3 Adrenergic Receptor antibody (AB76249)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (7)

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