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Rabbit Recombinant Monoclonal Amyloid-beta precursor protein antibody. Suitable for sELISA, WB and reacts with Synthetic peptide, Recombinant fragment samples. Cited in 1 publication.

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Images

Western blot - Anti-beta Amyloid 1-38 antibody [EPR1878(2)] (AB108253), expandable thumbnail
  • Sandwich ELISA - Anti-beta Amyloid 1-38 antibody [EPR1878(2)] (AB108253), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA

Form

Liquid

Clonality

Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
sELISAWB
Human
Predicted
Predicted
Recombinant fragment
Not recommended
Tested
Synthetic peptide
Tested
Not recommended

Tested
Tested

Species

Synthetic peptide

Dilution info
1 µg/mL
Notes

-

Predicted
Predicted

Species

Human

Dilution info

-

Notes

-

Not recommended
Not recommended

Species

Recombinant fragment

Dilution info

-

Notes

-

Tested
Tested

Species

Recombinant fragment

Dilution info
1/1000 - 1/10000
Notes

-

Predicted
Predicted

Species

Human

Dilution info

-

Notes

-

Not recommended
Not recommended

Species

Synthetic peptide

Dilution info

-

Notes

-

Target data

Function

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta protein 42 is a more effective reductant than amyloid-beta protein 40. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. APP42-beta may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain.The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.

Alternative names

Recommended products

Rabbit Recombinant Monoclonal Amyloid-beta precursor protein antibody. Suitable for sELISA, WB and reacts with Synthetic peptide, Recombinant fragment samples. Cited in 1 publication.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Monoclonal

Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Clone number

EPR1878(2)

Purification technique

Affinity purification Protein A

Specificity

ab108253 is specific to the cleaved peptide Abeta38.

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

Notes

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Beta Amyloid 1-38 also known as Aβ1-38 is a peptide that originates from the amyloid precursor protein (APP) through proteolytic processing. This peptide has a mass of approximately 4.17 kDa. Aβ1-38 is expressed in the brain and other tissues and it plays a role in the complex network of amyloidogenic processing. Its generation results from the sequential cleavage of APP by beta-secretase and gamma-secretase enzymes where it is one of the shorter forms of amyloid-beta peptides produced.

Biological function summary

Beta amyloid 1-38 participates in amyloid plaque formation which is significant in neurodegenerative processes. This peptide is part of a heterogenous group of amyloid-beta peptides which includes other forms like beta amyloid 1-40 and beta amyloid 1-42. Aβ1-38 contributes to the complex accumulation and aggregation of amyloid fibrils that have implications in synaptic functions and neuronal health. Its interactions influence cell signaling pathways and processes involved in cellular stress responses.

Pathways

Beta amyloid 1-38 plays a role in the amyloidogenesis pathway. This pathway impacts the regulation of synaptic activity and neural communication. The peptide is integrated into pathways connected with mitochondrial function and oxidative stress influencing how neurons react to metabolic demands. Proteins related to this pathway include presenilin which is a component of the gamma-secretase complex responsible for APP processing and tau protein which is involved in microtubule stability within cells.

Associated diseases and disorders

Beta amyloid 1-38 is important in the pathology of Alzheimer's disease. The peptide's accumulation contributes to the formation of amyloid plaques a hallmark of the disease. Another disorder linked to beta amyloid peptide aggregates is cerebral amyloid angiopathy where the deposition in cerebral vessels can lead to vascular damage. Aβ1-38's relationship with proteins such as tau which forms neurofibrillary tangles in Alzheimer's highlights shared pathogenic mechanisms in these disorders.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

2 product images

  • Western blot - Anti-beta Amyloid 1-38 antibody [EPR1878(2)] (ab108253), expandable thumbnail

    Western blot - Anti-beta Amyloid 1-38 antibody [EPR1878(2)] (ab108253)

    All lanes: Western blot - Anti-beta Amyloid 1-38 antibody [EPR1878(2)] (ab108253) at 1/1000 dilution

    Lane 1: Abeta38 protein at 10 µg

    Lane 2: Abeta40 protein at 10 µg

    Lane 3: Abeta42 protein at 10 µg

    Predicted band size: 86 kDa

  • Sandwich ELISA - Anti-beta Amyloid 1-38 antibody [EPR1878(2)] (ab108253), expandable thumbnail

    Sandwich ELISA - Anti-beta Amyloid 1-38 antibody [EPR1878(2)] (ab108253)

    ELISA of beta Amyloid 1-38 peptide at 2μg/mL. Detected with ab108253 at 0~500 pg/mL. Peroxidase Streptavidin SA-HRP at 1/20000 was used as a secondary antibody.

    Washing buffer: 1X PBST
    Blocking buffer: 1% BSA/PBS

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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