Anti-beta Catenin antibody [CTNNB1/2030R] - BSA and Azide free
- Recombinant
- What is this?
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(1 Publication)
Rabbit Recombinant Monoclonal beta Catenin antibody. Carrier free. Suitable for WB, Protein Array, IHC-P and reacts with Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CTNNB1.
View Alternative Names
CTNNB, OK/SW-cl.35, PRO2286, CTNNB1, Catenin beta-1, Beta-catenin
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Catenin antibody [CTNNB1/2030R] - BSA and Azide free (AB237826)
Formalin-fixed, paraffin-embedded human tonsil tissue stained for beta Catenin using ab237984 at 2 μg/ml in immunohistochemical analysis.
This data was produced with ab237984, the same antibody in a different formulation with BSA and Azide.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Catenin antibody [CTNNB1/2030R] - BSA and Azide free (AB237826)
Formalin-fixed, paraffin-embedded human cervical carcinoma tissue stained for beta Catenin using ab237984 at 2 μg/ml in immunohistochemical analysis.
This data was produced with ab237984, the same antibody in a different formulation with BSA and Azide.
- WB
Supplier Data
Western blot - Anti-beta Catenin antibody [CTNNB1/2030R] - BSA and Azide free (AB237826)
This data was produced with ab237984, the same antibody in a different formulation with BSA and Azide.
All lanes:
Western blot - Anti-beta Catenin antibody [CTNNB1/2030R] (<a href='/en-us/products/primary-antibodies/beta-catenin-antibody-ctnnb1-2030r-ab237984'>ab237984</a>) at 2 µg/mL
All lanes:
HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate
Predicted band size: 85 kDa
false
- Protein Array
Unknown
Protein Array - Anti-beta Catenin antibody [CTNNB1/2030R] - BSA and Azide free (AB237826)
This data was produced with ab237984, the same antibody in a different formulation with BSA and Azide.
ab237984 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Reactivity data
Product details
ab237826 is the carrier-free version of ab237984.
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Properties and storage information
Form
Purification technique
Purification notes
Storage buffer
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
This protein plays roles in both cell adhesion and the regulation of gene expression. Beta Catenin is a critical component of the Wnt signaling pathway where it can form complexes with other proteins to influence gene transcription. In the absence of Wnt signaling beta Catenin levels are low due to its degradation. However when the pathway is active it accumulates in the cytoplasm and eventually translocates to the nucleus where it interacts with TCF/LEF transcription factors to regulate the expression of target genes.
Pathways
Beta Catenin plays a central role in the Wnt signaling pathway and influences cell fate decisions and cellular proliferation. It acts in concert with proteins such as Dishevelled (DVL) and Axin to coordinate these important biological processes. In the absence of Wnt signaling proteins such as APC and GSK-3β are responsible for beta Catenin degradation keeping its cellular levels in check. Beta Catenin’s interaction with transcription factors in the nucleus makes it pivotal in the regulation of cell and tissue homeostasis.
Product protocols
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Target data
Publications (1)
Recent publications for all applications. Explore the full list and refine your search
iScience 25:105503 PubMed36404924
2022
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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