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AB135954

Anti-beta Sarcoglycan antibody

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(2 Publications)

Rabbit Polyclonal beta Sarcoglycan antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SGCB.

View Alternative Names

Beta-sarcoglycan, Beta-SG, 43 kDa dystrophin-associated glycoprotein, A3b, 43DAG, SGCB

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Sarcoglycan antibody (AB135954)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Sarcoglycan antibody (AB135954)

Immunohistochemical analysis of paraffin-embedded Human brain tissue labelling beta Sarcoglycan with ab135954 at 1/50 dilution.

Western blot - Anti-beta Sarcoglycan antibody (AB135954)
  • WB

Unknown

Western blot - Anti-beta Sarcoglycan antibody (AB135954)

All lanes:

Western blot - Anti-beta Sarcoglycan antibody (ab135954) at 1/500 dilution

All lanes:

A549 cell extract at 30 µg

Predicted band size: 35 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human SGCB. The exact immunogen used to generate this antibody is proprietary information.

Q16585

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Complementary Products

Primary Antibodies

AB189254

Anti-alpha Sarcoglycan antibody [EPR14773]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha Sarcoglycan antibody [EPR14773] (AB189254)

  • 0
  • 0
Primary Antibodies

AB234587

Anti-DAG1 antibody [IIH6C4]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DAG1 antibody [IIH6C4] (AB234587)

  • 0
  • 0
Primary Antibodies

AB137101

Anti-delta Sarcoglycan antibody [EPR8706]

BOND RX™ Validated|20ul selling size|Recombinant|Advanced Validation|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-delta Sarcoglycan antibody [EPR8706] (AB137101)

  • 0
  • 0
Primary Antibodies

AB15277

Anti-Dystrophin antibody

Immunohistochemistry - Anti-Dystrophin antibody (AB15277)

  • 4
  • 23
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Beta Sarcoglycan is a glycoprotein that has different names including 35DAG or A3b. It plays an important role in muscle cells by integrating into the sarcoglycan complex. This protein has an approximate mass of 43 kDa. It is mainly expressed in skeletal and cardiac muscle tissues. Beta Sarcoglycan provides structural support to the muscle cell membrane by linking inside the dystrophin-associated glycoprotein complex (DGC).
Biological function summary

Beta Sarcoglycan acts to maintain the stability of the muscle cell's sarcolemma. It forms part of the sarcoglycan complex which is one component of a larger dystrophin-glycoprotein complex. This complex protects muscle fibers from the stress of contraction. By ensuring the integrity of the muscle membrane Beta Sarcoglycan contributes to muscle fiber repair and regeneration reducing the risk of damage from repetitive use.

Pathways

Beta Sarcoglycan belongs to the dystrophin-associated glycoprotein complex playing a role in the linkage between the cytoskeleton and extracellular matrix. This involvement occurs primarily in the DGC signaling pathway. The interaction with dystrophin and other sarcoglycans ensures effective signal transduction and mechanical stability during muscle contraction. It relates to proteins including dystrophin itself and other sarcoglycans like alpha and gamma that cooperate in the same pathway.

Beta Sarcoglycan connects closely to limb-girdle muscular dystrophy (LGMD). Mutations in the gene encoding this protein lead to muscle weakness and degeneration characteristic of LGMD. It has a direct relationship with other sarcoglycans like gamma and alpha as defects in these proteins can cause similar dystrophic conditions. The impaired function of Beta Sarcoglycan results in the breakdown of muscle membrane integrity contributing to the progression of the disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
See full target information SGCB
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 27:97 PubMed38356676

2024

Identification and functional characterization of a novel heterozygous splice‑site mutation in the calpain 3 gene causes rare autosomal dominant limb‑girdle muscular dystrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Mao,Jie Yang,Xiaodong Zhao,Xueling Jia,Xin Shi,Lihui Zhao,Santasree Banerjee,Lili Zhang,Xiaoling Ma

Cellular physiology and biochemistry : internation 49:2099-2110 PubMed30257238

2018

Propofol Inhibits Proliferation, Migration, Invasion and Promotes Apoptosis Through Down-Regulating miR-374a in Hepatocarcinoma Cell Lines.

Applications

Unspecified application

Species

Unspecified reactive species

Sheng-Qun Liu,Jing-Liang Zhang,Zhan-Wen Li,Zhen-Hua Hu,Zhe Liu,Yi Li
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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