Rabbit Polyclonal beta Synuclein antibody. Suitable for IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human SNCB aa 100 to C-terminus.
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- Cells 12:2023Interneuronal In Vivo Transfer of Synaptic Proteins.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMichael Klinkenberg,Michael Helwig,Rita Pinto-Costa,Angela Rollar,Raffaella Rusconi,Donato A Di Monte,Ayse UlusoyPubMed 36831238
- Disease models & mechanisms 10:619-6312017Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSuna Lahut et. al.PubMed 28108469
- Journal of neuroscience research 94:717-352016LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShubhangi Prabhudesai,Fatima Zahra Bensabeur,Rashed Abdullah,Indranil Basak,Solange Baez,Guido Alves,Nathalia G Holtzman,Jan Petter Larsen,Simon Geir MøllerPubMed 27265751
- Brain : a journal of neurology 139:856-702016Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice.Applications:WBReactive species:MouseMichael Helwig,Michael Klinkenberg,Raffaella Rusconi,Ruth E Musgrove,Nour K Majbour,Omar M A El-Agnaf,Ayse Ulusoy,Donato A Di MontePubMed 26719384
- Neuropathology and applied neurobiology 38:737-432012Pick's pathology in Parkinson's disease with dementia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesD Vilas,M J Marti,T Botta-Orfila,M Colom-Cadena,E GelpiPubMed 22686686
- Brain : a journal of neurology 133:3724-332010The decrease of β-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies.
- The Journal of biological chemistry 276:45320-92001alpha-Synuclein affects the MAPK pathway and accelerates cell death.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7 - 7.4
- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Synthetic Peptide within Human SNCB aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q16143
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Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/2000 | Notes - |
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Target data
Function
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Alternative names
Beta-synuclein, SNCB
Recommended products
Rabbit Polyclonal beta Synuclein antibody. Suitable for IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human SNCB aa 100 to C-terminus.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7 - 7.4
- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Synthetic Peptide within Human SNCB aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q16143
- Purity
Whole antiserum
- Specificity
Less than 0.1% cross reactivity against human alpha-synuclein
Cross reactivity: This antibody is known to react with human and rat. Not yet tested in other species.- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Add glycerol to a final volume of 50% for extra stability and aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Beta-synuclein also known as β-synuclein or SNCB is a protein that plays a role in the nervous system. It is a small protein with a molecular weight around 14 kDa. Predominantly beta-synuclein is found in presynaptic terminals of neurons in the central nervous system including the brain and spinal cord. This protein shares significant amino acid sequence identity with alpha-synuclein and gamma-synuclein comprising the synuclein family. It acts as a modulator of neuronal and synaptic function influencing the dynamics of neurotransmitter release.
- Biological function summary
Beta-synuclein contributes to cellular homeostasis and synaptic integrity. It is not typically found as part of a larger protein complex like its relative alpha-synuclein which forms toxic aggregates. Instead beta-synuclein exhibits neuroprotective properties helping maintain neuronal health. It possibly regulates synaptic vesicle cycling and mitigates levels of alpha-synuclein aggregation. Research suggests that loss of beta-synuclein function might disrupt synaptic stability leading to neurological issues.
- Pathways
Beta-synuclein engages in synaptic function and plasticity. It participates in pathways related to neurotransmitter release and synaptic vesicle trafficking. Beta-synuclein is connected to calcium/calmodulin-dependent protein kinase II (CaMKII) pathways. This interaction supports beta-synuclein's regulatory impact on synaptic vesicle dynamics negatively modulating the aggregation-prone behaviors seen in alpha-synuclein during synucleinopathies.
- Associated diseases and disorders
Beta-synuclein plays a role in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Research highlights its relationship with these conditions due to its interaction with alpha-synuclein known to form pathological aggregates and contribute to disease progression. Beta-synuclein's modulation of alpha-synuclein activity can impact the development and progression of these disorders. There is ongoing interest in its potential protective role suggesting it might be leveraged in therapeutic strategies against synucleinopathy-related diseases.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Synuclein antibody (ab6165)
ab6165 staining beta synuclein in human occipital cortex.
Left panel: with primary antibody diluted 1:4000. Right panel: isotype control.
Sections were stained using an automated system (DAKO Autostainer Plus), at room temperature: sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffers citrate pH6.1. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako envision flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.
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