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AB168167

Anti-Betatrophin antibody

3

(1 Review)

|

(1 Publication)

Mouse Polyclonal Betatrophin antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ANGPTL8.

View Alternative Names

C19orf80, RIFL, UNQ599/PRO1185, ANGPTL8, Angiopoietin-like protein 8, Betatrophin, Lipasin, Refeeding-induced fat and liver protein

1 Images
Western blot - Anti-Betatrophin antibody (AB168167)
  • WB

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Western blot - Anti-Betatrophin antibody (AB168167)

All lanes:

Western blot - Anti-Betatrophin antibody (ab168167) at 1 µg/mL

Lane 1:

Betatrophin transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG HRP at 1/2500 dilution

Predicted band size: 22 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ANGPTL8.

Q6UXH0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Betatrophin also known as ANGPTL8 or Lipasin is a protein involved in metabolic regulation. It has a molecular mass of approximately 22 kDa. The liver and adipose tissue mainly express this protein. Betatrophin plays a significant role in energy balance by influencing lipid metabolism making it an important factor in managing metabolic processes in the body.
Biological function summary

Betatrophin regulates the proliferation of pancreatic beta cells which are important for insulin production. It does not form part of a larger protein complex. Its expression can increase in response to metabolic demands linking it closely with the mechanisms of energy utilization and storage.

Pathways

Betatrophin interacts closely with lipid metabolism and glucose homeostasis. It influences the insulin signaling pathway and is interconnected with the regulation of triglyceride levels. In the context of these pathways betatrophin collaborates with proteins like ANGPTL3 to modulate lipid breakdown and storage playing an important part in metabolic balance.

Betatrophin is associated with Type 2 diabetes and obesity. Its role in inducing pancreatic beta cell proliferation makes it a point of interest for managing insulin resistance a common feature of diabetes. Proteins like ANGPTL4 also interact with betatrophin influencing lipid metabolism and linking to disorders such as obesity. Understanding betatrophin's function and regulation offers potential therapeutic targets for these metabolic diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed : 22569073, PubMed : 22809513, PubMed : 23150577). May be involved in the metabolic transition between fasting and refeeding : required to direct fatty acids to adipose tissue for storage in the fed state (By similarity).
See full target information ANGPTL8
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer medicine 7:5194-5204 PubMed30259711

2018

Expression of sushi domain containing two reflects the malignant potential of gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Shinichi Umeda,Mitsuro Kanda,Takashi Miwa,Haruyoshi Tanaka,Chie Tanaka,Daisuke Kobayashi,Masaya Suenaga,Norifumi Hattori,Masamichi Hayashi,Suguru Yamada,Goro Nakayama,Michitaka Fujiwara,Yasuhiro Kodera
View all publications
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