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AB180915

Anti-Betatrophin antibody - N-terminal

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(4 Publications)

Rabbit Polyclonal Betatrophin antibody. N-terminal. Suitable for WB, IHC-P and reacts with Rat, Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ANGPTL8.

View Alternative Names

C19orf80, RIFL, UNQ599/PRO1185, ANGPTL8, Angiopoietin-like protein 8, Betatrophin, Lipasin, Refeeding-induced fat and liver protein

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Betatrophin antibody - N-terminal (AB180915)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Betatrophin antibody - N-terminal (AB180915)

Immunohistochemistry of Betatrophin in rat liver tissue with ab180915 at 5 μg/mL.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Betatrophin antibody - N-terminal (AB180915)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Betatrophin antibody - N-terminal (AB180915)

Immunofluorescence of Betatrophin in rat liver tissue with ab180915 at 20 μg/mL.

Western blot - Anti-Betatrophin antibody - N-terminal (AB180915)
  • WB

Supplier Data

Western blot - Anti-Betatrophin antibody - N-terminal (AB180915)

Lane 1:

Western blot - Anti-Betatrophin antibody - N-terminal (ab180915) at 1 µg/mL

Lane 2:

Western blot - Anti-Betatrophin antibody - N-terminal (ab180915) at 2 µg/mL

All lanes:

Rat liver tissue lysate at 15 µg

Predicted band size: 22 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human, Mouse

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human ANGPTL8. The exact immunogen used to generate this antibody is proprietary information.

Q6UXH0

Specificity

At least three isoforms of Betatrophin are known to exist (NP_061157, AAF76204 / EAW84186, EAW84185). ab180915 will detect the two largest isoforms of Betatrophin.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Betatrophin also known as ANGPTL8 or Lipasin is a protein involved in metabolic regulation. It has a molecular mass of approximately 22 kDa. The liver and adipose tissue mainly express this protein. Betatrophin plays a significant role in energy balance by influencing lipid metabolism making it an important factor in managing metabolic processes in the body.
Biological function summary

Betatrophin regulates the proliferation of pancreatic beta cells which are important for insulin production. It does not form part of a larger protein complex. Its expression can increase in response to metabolic demands linking it closely with the mechanisms of energy utilization and storage.

Pathways

Betatrophin interacts closely with lipid metabolism and glucose homeostasis. It influences the insulin signaling pathway and is interconnected with the regulation of triglyceride levels. In the context of these pathways betatrophin collaborates with proteins like ANGPTL3 to modulate lipid breakdown and storage playing an important part in metabolic balance.

Betatrophin is associated with Type 2 diabetes and obesity. Its role in inducing pancreatic beta cell proliferation makes it a point of interest for managing insulin resistance a common feature of diabetes. Proteins like ANGPTL4 also interact with betatrophin influencing lipid metabolism and linking to disorders such as obesity. Understanding betatrophin's function and regulation offers potential therapeutic targets for these metabolic diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed : 22569073, PubMed : 22809513, PubMed : 23150577). May be involved in the metabolic transition between fasting and refeeding : required to direct fatty acids to adipose tissue for storage in the fed state (By similarity).
See full target information ANGPTL8
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:4436 PubMed37481670

2023

LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Dan-Pei Li,Li Huang,Ran-Ran Kan,Xiao-Yu Meng,Shu-Yun Wang,Hua-Jie Zou,Ya-Ming Guo,Pei-Qiong Luo,Li-Meng Pan,Yu-Xi Xiang,Bei-Bei Mao,Yu-Yu Xie,Zhi-Han Wang,Min Yang,Rui He,Yan Yang,Zhe-Long Liu,Jun-Hui Xie,De-Lin Ma,Ben-Ping Zhang,Shi-Ying Shao,Xi Chen,Si-Miao Xu,Wen-Tao He,Wen-Jun Li,Yong Chen,Xue-Feng Yu

Oncogenesis 12:26 PubMed37188659

2023

Dual role of ANGPTL8 in promoting tumor cell proliferation and immune escape during hepatocarcinogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yujiu Gao,Yue Yuan,Shu Wen,Yanghui Chen,Zongli Zhang,Ying Feng,Bin Jiang,Shinan Ma,Rong Hu,Chen Fang,Xuzhi Ruan,Yahong Yuan,Xinggang Fang,Chao Luo,Zhongji Meng,Xiaoli Wang,Xingrong Guo

Molecular medicine reports 20:4523-4532 PubMed31702044

2019

Recombinant betatrophin (Angptl‑8/lipasin) ameliorates streptozotocin‑induced hyperglycemia and β‑cell destruction in neonatal rats.

Applications

Unspecified application

Species

Unspecified reactive species

Di Zhang,Yan-Juan Yu,Feng-Sen Xu,Jun-Hua Yuan,Rui Wang,Cai-Shun Zhang,Liu-Xin Wang,Yuan Liu,Li-Min Song,Jun-Li Liu,Jing Dong

Frontiers in molecular neuroscience 11:451 PubMed30618603

2018

Neuropeptide Y-Positive Neurons in the Dorsomedial Hypothalamus Are Involved in the Anorexic Effect of Angptl8.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Wang,Junhua Yuan,Caishun Zhang,Liuxin Wang,Yuan Liu,Limin Song,Weizhen Zhong,Xi Chen,Jing Dong
View all publications
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