JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB226991

Anti-Biglycan antibody

Be the first to review this product! Submit a review

|

(4 Publications)

Rabbit Polyclonal Biglycan antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BGN.

View Alternative Names

SLRR1A, BGN, Biglycan, Bone/cartilage proteoglycan I, PG-S1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Biglycan antibody (AB226991)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Biglycan antibody (AB226991)

Paraffin-embedded human colon epithelium tissue stained for Biglycan using ab226991 at 1/250 dilution in immunohistochemical analysis.

Western blot - Anti-Biglycan antibody (AB226991)
  • WB

Supplier Data

Western blot - Anti-Biglycan antibody (AB226991)

12% SDS-PAGE gel.

All lanes:

Western blot - Anti-Biglycan antibody (ab226991) at 1/500 dilution

All lanes:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 30 µg

Predicted band size: 42 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human BGN. The exact immunogen used to generate this antibody is proprietary information.

P21810

style
left-column

Alternative Products

Primary Antibodies

AB58562

Anti-Biglycan antibody

Immunocytochemistry - Anti-Biglycan antibody (AB58562)

  • 3
  • 5
Primary Antibodies

AB231297

Anti-Biglycan antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Biglycan antibody (AB231297)

  • 0
  • 0
Primary Antibodies

AB209234

Anti-Biglycan antibody [EPR20235]

RabMAb|Recombinant|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Biglycan antibody [EPR20235] (AB209234)

  • 5
  • 1
Primary Antibodies

AB109369

Anti-Biglycan antibody [EPR2959]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Biglycan antibody [EPR2959] (AB109369)

  • 1
  • 1
Primary Antibodies

AB188508

Anti-Biglycan antibody

Western blot - Anti-Biglycan antibody (AB188508)

  • 0
  • 0

Complementary Products

Assay Kits

AB245709

Human Biglycan ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human Biglycan ELISA Kit (AB245709)

  • 0
  • 0
Primary Antibodies

AB168348

Anti-Lumican antibody [EPR8898(2)]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lumican antibody [EPR8898(2)] (AB168348)

  • 5
  • 16
Primary Antibodies

AB138492

Anti-Collagen I antibody [EPR7785]

20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Frozen sections) - Anti-Collagen I antibody [EPR7785] (AB138492)

  • 4
  • 37
Primary Antibodies

AB177480

Anti-Versican antibody [EPR12277]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Versican antibody [EPR12277] (AB177480)

  • 4
  • 3
Primary Antibodies

AB189524

Anti-CD44 antibody [EPR18668]

RabMAb|Recombinant|Lab Essentials|20ul selling size|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD44 antibody [EPR18668] (AB189524)

  • 5
  • 1
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Sheep": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biglycan also known as BGN is a small leucine-rich proteoglycan with a molecular weight of roughly 38 kDa. Researchers frequently observe Biglycan in tissues such as bone cartilage and vasculature. The protein interacts with several other molecules in the extracellular matrix (ECM) including collagen and elastin to maintain the structural integrity of tissues. Through these interactions Biglycan plays an important role in supporting cell attachment and matrix organization.
Biological function summary

The protein Biglycan influences cellular processes such as growth and differentiation. It is part of a complex network within the ECM that modulates cell signaling. Biglycan interacts with growth factors like transforming growth factor-beta (TGF-beta) and binds to Toll-like receptors (TLRs) affecting immune responses. These capabilities reveal Biglycan’s involvement in tissue development and repair.

Pathways

Extracellular matrix modulation shows a significant role for Biglycan. It is involved in the TGF-beta signaling pathway and the inflammatory pathway mediated by TLRs. Through these pathways Biglycan interacts with proteins such as decorin and fibromodulin contributing to the regulation of collagen fibrillogenesis and inflammatory responses. Its role in these pathways highlights Biglycan’s influence in cellular communication and matrix regulation.

Biglycan has associations with osteoarthritis and muscular dystrophy. In osteoarthritis researchers observe altered expression levels of Biglycan which affects cartilage integrity. In muscular dystrophy the protein’s connection to dystrophin an important structural protein is noted. These associations illustrate Biglycan's impact on disease progression and its potential as a therapeutic target.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May be involved in collagen fiber assembly.
See full target information BGN
style
left-column

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Acta biochimica et biophysica Sinica 57:712-726 PubMed39578715

2024

PDK1 promotes epithelial ovarian cancer progression by upregulating BGN.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Zhang,Lina Yan,Xin Fu,Ziqi Tao,Shuna Liu,Rong Li,Ting Wang,Yepeng Mao,Wenwen Shang,Mi Gong,Xuemei Jia,Fang Wang

Frontiers in immunology 15:1367432 PubMed38994364

2024

The mammosphere-derived epithelial cell secretome modulates neutrophil functions in the bovine model.

Applications

Unspecified application

Species

Unspecified reactive species

Rebecca M Harman,Anja Sipka,Kelly A Oxford,Leane Oliveira,Lucas Huntimer,Daryl V Nydam,Gerlinde R Van de Walle

Biomacromolecules 25:5786-5797 PubMed38935055

2024

Polysaccharide-Containing Carboxymethyl Cellulose Bilayer Structure Membrane for Prevention of Postoperative Adhesion and Achilles Tendon Repair.

Applications

Unspecified application

Species

Unspecified reactive species

Zhi-Yu Chen,Shih-Heng Chen,Shih-Hsien Chen,Pang-Yun Chou,Che-Yung Kuan,I-Hsuan Yang,Chia-Tien Chang,Yi-Chun Su,Feng-Huei Lin

International journal of molecular sciences 22: PubMed34830254

2021

Extracellular Vesicles of Adipose-Derived Stem Cells Promote the Healing of Traumatized Achilles Tendons.

Applications

Unspecified application

Species

Unspecified reactive species

Shih-Heng Chen,Zhi-Yu Chen,Ya-Hsuan Lin,Shih-Hsien Chen,Pang-Yun Chou,Huang-Kai Kao,Feng-Huei Lin
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com