Goat Polyclonal Biglycan antibody. Suitable for ICC and reacts with Mouse, Human samples. Cited in 22 publications. Immunogen corresponding to Synthetic Peptide within Human BGN aa 350 to C-terminus.
IgG
Goat
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 0.5% Tris buffered saline
Liquid
Polyclonal
ICC | |
---|---|
Human | Tested |
Mouse | Tested |
Rat | Predicted |
Dog | Predicted |
Horse | Predicted |
Pufferfish | Predicted |
Sheep | Predicted |
Xenopus laevis | Predicted |
Zebrafish | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Human | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Rat, Sheep, Horse, Dog, Xenopus laevis, Pufferfish, Zebrafish | Dilution info - | Notes - |
Select an associated product type
Biglycan, Bone/cartilage proteoglycan I, PG-S1, SLRR1A, BGN
Goat Polyclonal Biglycan antibody. Suitable for ICC and reacts with Mouse, Human samples. Cited in 22 publications. Immunogen corresponding to Synthetic Peptide within Human BGN aa 350 to C-terminus.
Biglycan, Bone/cartilage proteoglycan I, PG-S1, SLRR1A, BGN
IgG
Goat
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 0.5% Tris buffered saline
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
Biglycan also known as BGN is a small leucine-rich proteoglycan with a molecular weight of roughly 38 kDa. Researchers frequently observe Biglycan in tissues such as bone cartilage and vasculature. The protein interacts with several other molecules in the extracellular matrix (ECM) including collagen and elastin to maintain the structural integrity of tissues. Through these interactions Biglycan plays an important role in supporting cell attachment and matrix organization.
The protein Biglycan influences cellular processes such as growth and differentiation. It is part of a complex network within the ECM that modulates cell signaling. Biglycan interacts with growth factors like transforming growth factor-beta (TGF-beta) and binds to Toll-like receptors (TLRs) affecting immune responses. These capabilities reveal Biglycan’s involvement in tissue development and repair.
Extracellular matrix modulation shows a significant role for Biglycan. It is involved in the TGF-beta signaling pathway and the inflammatory pathway mediated by TLRs. Through these pathways Biglycan interacts with proteins such as decorin and fibromodulin contributing to the regulation of collagen fibrillogenesis and inflammatory responses. Its role in these pathways highlights Biglycan’s influence in cellular communication and matrix regulation.
Biglycan has associations with osteoarthritis and muscular dystrophy. In osteoarthritis researchers observe altered expression levels of Biglycan which affects cartilage integrity. In muscular dystrophy the protein’s connection to dystrophin an important structural protein is noted. These associations illustrate Biglycan's impact on disease progression and its potential as a therapeutic target.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Immunocytochemistry analysis of paraformaldehyde fixed, 0.15% Triton X 100 permeabilized HepG2 cells staining biglycan with ab58562 at 10μg/ml, followed by Alexa Fluor 488 secondary antibody at 2μg/ml (green). Nuclei counterstained with DAPI (blue).
Negative control: Unimmunized goat IgG (10μg/ml) followed by Alexa Fluor 488 secondary antibody (2μg/ml).
Immunocytochemistry analysis of paraformaldehyde fixed, 0.15% Triton X 100 permeabilized NIH3T3 cells staining biglycan with ab58562 at 10μg/ml, followed by Alexa Fluor 488 secondary antibody at 2μg/ml (green). Nuclei counterstained with DAPI (blue).
Negative control: Unimmunized goat IgG (10μg/ml) followed by Alexa Fluor 488 secondary antibody (2μg/ml).
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