Goat Polyclonal Biglycan antibody. Suitable for ICC and reacts with Mouse, Human samples. Cited in 22 publications. Immunogen corresponding to Synthetic Peptide within Human BGN aa 350 to C-terminus.
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- Liver international : official journal of the International Association for the Study of the Liver 43:500-5122022Biglycan promotes hepatic fibrosis through activating heat shock protein 47.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMengli Yu,Xinjue He,Xin Song,Jianguo Gao,Jiaqi Pan,Tianyu Zhou,Qinqiu Wang,Wei Zhu,Huijian Ma,Hang Zeng,Chengfu Xu,Chaohui YuPubMed 36371672
- Acta biochimica et biophysica Sinica 54:243-2512022Aberrant expression of the extracellular matrix component Biglycan regulated by Hedgehog signalling promotes colorectal cancer cell proliferation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShaopeng Zeng,Feifei Zhou,Yiqing Wang,Zhenyu Zhai,Linlin Xu,Hailong Wang,Xinping Chen,Shiwen Luo,Minzhang ChengPubMed 35130618
- Journal of cellular and molecular medicine 25:4195-42032021Bmi1 regulate tooth and mandible development by inhibiting p16 signal pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing Yin,Nan Zhou,Hui Zhang,Xiuliang Dai,Xianhui Lv,Ning Chen,Dengshun Miao,Qingang HuPubMed 33745198
- Aging 11:7257-72732019Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChao Zhou et. al.PubMed 31509519
- In vitro cellular & developmental biology. Animal 55:211-2192019Effect of attenuation of fibroblast growth factor receptor 2b signaling on odontoblast differentiation and dentin formation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMiyuki Yokoi et. al.PubMed 30756235
- Journal of muscle research and cell motility 38:251-2682017Proteomic profiling of the dystrophin complex and membrane fraction from dystrophic mdx muscle reveals decreases in the cytolinker desmoglein and increases in the extracellular matrix stabilizers biglycan and fibronectin.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSandra Murphy et. al.PubMed 28803268
- European cells & materials 32:228-2402016Periodontal ligament cells as alternative source for cell-based therapy of tendon injuries: in vivo study of full-size Achilles tendon defect in a rat model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesC-F Hsieh et. al.PubMed 27763655
- PloS one 10:e01281632015Foam Cell Formation In Vivo Converts Macrophages to a Pro-Fibrotic Phenotype.
- The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 63:8-212014Study of the development of the mouse thoracic aorta three-dimensional macromolecular structure using two-photon microscopy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLeah M Zadrozny,Edward B Neufeld,Bertrand M Lucotte,Patricia S Connelly,Zu-Xi Yu,Lam Dao,Li-Yueh Hsu,Robert S BalabanPubMed 25362141
- Atherosclerosis 237:471-92014Biglycan expression in current cigarette smokers: a possible link between active smoking and atherogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesG Mandraffino et. al.PubMed 25463076
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 0.5% Tris buffered saline- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human BGN aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P21810
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Reactivity data
Select an application| ICC | |
|---|---|
| Human | Tested |
| Mouse | Tested |
| Rat | Predicted |
| Dog | Predicted |
| Horse | Predicted |
| Pufferfish | Predicted |
| Sheep | Predicted |
| Xenopus laevis | Predicted |
| Zebrafish | Predicted |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Human | Dilution info - | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Sheep, Horse, Dog, Xenopus laevis, Pufferfish, Zebrafish | Dilution info - | Notes - |
Associated Products
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4 products for Alternative Product
Alternative names
SLRR1A, BGN, Biglycan, Bone/cartilage proteoglycan I, PG-S1
Recommended products
Goat Polyclonal Biglycan antibody. Suitable for ICC and reacts with Mouse, Human samples. Cited in 22 publications. Immunogen corresponding to Synthetic Peptide within Human BGN aa 350 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 0.5% Tris buffered saline- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human BGN aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P21810
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Biglycan also known as BGN is a small leucine-rich proteoglycan with a molecular weight of roughly 38 kDa. Researchers frequently observe Biglycan in tissues such as bone cartilage and vasculature. The protein interacts with several other molecules in the extracellular matrix (ECM) including collagen and elastin to maintain the structural integrity of tissues. Through these interactions Biglycan plays an important role in supporting cell attachment and matrix organization.
- Biological function summary
The protein Biglycan influences cellular processes such as growth and differentiation. It is part of a complex network within the ECM that modulates cell signaling. Biglycan interacts with growth factors like transforming growth factor-beta (TGF-beta) and binds to Toll-like receptors (TLRs) affecting immune responses. These capabilities reveal Biglycan’s involvement in tissue development and repair.
- Pathways
Extracellular matrix modulation shows a significant role for Biglycan. It is involved in the TGF-beta signaling pathway and the inflammatory pathway mediated by TLRs. Through these pathways Biglycan interacts with proteins such as decorin and fibromodulin contributing to the regulation of collagen fibrillogenesis and inflammatory responses. Its role in these pathways highlights Biglycan’s influence in cellular communication and matrix regulation.
- Associated diseases and disorders
Biglycan has associations with osteoarthritis and muscular dystrophy. In osteoarthritis researchers observe altered expression levels of Biglycan which affects cartilage integrity. In muscular dystrophy the protein’s connection to dystrophin an important structural protein is noted. These associations illustrate Biglycan's impact on disease progression and its potential as a therapeutic target.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunocytochemistry - Anti-Biglycan antibody (ab58562)
Immunocytochemistry analysis of paraformaldehyde fixed, 0.15% Triton X 100 permeabilized HepG2 cells staining biglycan with ab58562 at 10μg/ml, followed by Alexa Fluor 488 secondary antibody at 2μg/ml (green). Nuclei counterstained with DAPI (blue).
Negative control: Unimmunized goat IgG (10μg/ml) followed by Alexa Fluor 488 secondary antibody (2μg/ml).
Immunocytochemistry - Anti-Biglycan antibody (ab58562)
Immunocytochemistry analysis of paraformaldehyde fixed, 0.15% Triton X 100 permeabilized NIH3T3 cells staining biglycan with ab58562 at 10μg/ml, followed by Alexa Fluor 488 secondary antibody at 2μg/ml (green). Nuclei counterstained with DAPI (blue).
Negative control: Unimmunized goat IgG (10μg/ml) followed by Alexa Fluor 488 secondary antibody (2μg/ml).
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