AB27796

Anti-BIN1 antibody

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(3 Publications)

Rabbit Polyclonal BIN1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Mouse Bin1.

View Alternative Names

AMPHL, BIN1, Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1

1 Images

Unknown

Western blot - Anti-BIN1 antibody (AB27796)

All lanes:

Western blot - Anti-BIN1 antibody (ab27796) at 2 µg/mL

Lane 1:

Western blot - Jurkat whole cell lysate (<a href='/en-us/products/cell-lysates/jurkat-whole-cell-lysate-ab7899'>ab7899</a>)

Lane 2:

Jurkat cells treated with camptothecin for 6 hours

Predicted band size: 65 kDa

Observed band size: 48 kDa,64 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Mouse Bin1. The exact immunogen used to generate this antibody is proprietary information.

O08539

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" } } }

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 3672 Bin1 Antibody. 3672-100 is the same size as the 100 µg size of ab27796.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.02% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed : 24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed : 27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed : 8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed : 28893863).

See full target information BIN1

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of experimental & clinical cancer research : CR 44:141 PubMed40346580

2025

Tumor cell-intrinsic BIN1 deficiency promotes the immunosuppression and impedes ferroptosis of non-small cell lung cancer via G3BP1-mediated degradation of STAT1.

Applications

Unspecified application

Species

Unspecified reactive species

Jiali Wang,Yunlong Jia,Tianxu Liu,Xinyan Liu,Shuxian Yin,Jiaqi Chen,Xiaoqing Xu,Yi Zhang,Lihua Liu

Acta neuropathologica communications 10:4 PubMed34998435

2022

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.

Applications

Unspecified application

Species

Unspecified reactive species

Erwan Lambert,Orthis Saha,Bruna Soares Landeira,Ana Raquel Melo de Farias,Xavier Hermant,Arnaud Carrier,Alexandre Pelletier,Johanna Gadaut,Lindsay Davoine,Cloé Dupont,Philippe Amouyel,Amélie Bonnefond,Frank Lafont,Farida Abdelfettah,Patrik Verstreken,Julien Chapuis,Nicolas Barois,Fabien Delahaye,Bart Dermaut,Jean-Charles Lambert,Marcos R Costa,Pierre Dourlen

Molecular psychiatry 18:1225-34 PubMed23399914

2013

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.

Applications

Species

Human

J Chapuis,F Hansmannel,M Gistelinck,A Mounier,C Van Cauwenberghe,K V Kolen,F Geller,Y Sottejeau,D Harold,P Dourlen,B Grenier-Boley,Y Kamatani,B Delepine,F Demiautte,D Zelenika,N Zommer,M Hamdane,C Bellenguez,J-F Dartigues,J-J Hauw,F Letronne,A-M Ayral,K Sleegers,A Schellens,L V Broeck,S Engelborghs,P P De Deyn,R Vandenberghe,M O'Donovan,M Owen,J Epelbaum,M Mercken,E Karran,M Bantscheff,G Drewes,G Joberty,D Campion,J-N Octave,C Berr,M Lathrop,P Callaerts,D Mann,J Williams,L Buée,I Dewachter,C Van Broeckhoven,P Amouyel,D Moechars,B Dermaut,J-C Lambert

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-BIN1 antibody

Western blot - Anti-BIN1 antibody (AB27796)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Product protocols

Target data

Publications (3)

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