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AB84029

Biotin Anti-APRIL/TNFSF13 antibody

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(1 Publication)

Rabbit Polyclonal APRIL/TNFSF13 antibody - conjugated to Biotin. Suitable for WB, sELISA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TNFSF13.

View Alternative Names

CD256, APRIL, TALL2, ZTNF2, UNQ383/PRO715, TNFSF13, Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand, TNF- and APOL-related leukocyte expressed ligand 2, TNF-related death ligand 1, TALL-2, TRDL-1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Human

Applications

sELISA, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TNFSF13.

O75888

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Alternative Products

Primary Antibodies

AB108206

Anti-APRIL/TNFSF13 antibody [EPR4286]

RabMAb|Recombinant

Western blot - Anti-APRIL/TNFSF13 antibody [EPR4286] (AB108206)

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  • 1
Primary Antibodies

AB189263

Anti-APRIL/TNFSF13 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APRIL/TNFSF13 antibody (AB189263)

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  • 0

Complementary Products

Assay Kits

AB119505

Human APRIL ELISA Kit

Sandwich ELISA - Human APRIL ELISA Kit (AB119505)

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Primary Antibodies

AB229021

Anti-CD134 / OX40L receptor antibody [EPR22229-5]

BOND RX™ Validated|RabMAb|Recombinant

Flow Cytometry - Anti-CD134 / OX40L receptor antibody [EPR22229-5] (AB229021)

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Assay Kits

AB119505

Human APRIL ELISA Kit

Sandwich ELISA - Human APRIL ELISA Kit (AB119505)

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Primary Antibodies

AB181547

Anti-Insulin antibody [EPR17359]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Multiplex immunohistochemistry - Anti-Insulin antibody [EPR17359] (AB181547)

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Primary Antibodies

AB321167

Alexa Fluor® 750 Anti-Aspartate Aminotransferase + FABP-1 antibody [EPR12145]

Recombinant|RabMAb

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Centrifuge vial prior to opening. Reconstitute in 50 µl sterile PBS containing 0.1% BSA to give a concentration of 1.0 mg/ml.
Purification technique
Affinity purification Protein A
Purification notes
ab84029 is a sterile filtered antibody solution.
Storage buffer
Constituents: PBS, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

APRIL also known as TNFSF13 is a member of the tumor necrosis factor (TNF) ligand superfamily. This protein has a mass of approximately 31 kDa and undergoes incorporation into different cellular processes. APRIL is mainly expressed in cells of the immune system such as T cells B cells and myeloid cells. The protein plays a critical role in modulating various biological activities including cell survival proliferation and apoptosis.
Biological function summary

APRIL functions as a cytokine involved in immune regulation. The molecule acts independently or as part of a ligand-receptor interaction binding specifically to receptors like BCMA and TACI. This interaction influences B-cell maturation and differentiation driving immune responses. APRIL helps maintain homeostasis within the immune system ensuring appropriate immune activation and preventing overactive immune responses.

Pathways

APRIL coordinates with several immune-related pathways notably the B-cell signaling pathway and the NF-kB signaling pathway. These pathways are essential in immune system modulation influencing how the body responds to pathogens. APRIL interacts with proteins such as BAFF (B-cell activating factor) which share common receptors shaping the immune response through these pathways and ensuring proper immune cell function.

APRIL has connections with conditions like autoimmune diseases and certain lymphomas. Elevated levels of APRIL often occur in diseases like lupus contributing to abnormal B-cell activity and autoantibody production. Additionally its involvement in lymphomas links to excessive proliferation of B cells. Proteins such as BAFF and their receptors play a significant role in these conditions highlighting APRIL's impact on disease mechanisms and potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
See full target information TNFSF13
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 14:125 PubMed36792587

2023

NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via mC methylation.

Applications

Unspecified application

Species

Unspecified reactive species

Min Yang,Renxiong Wei,Sheng Zhang,Sang Hu,Xiaoxiao Liang,Zhiqiang Yang,Chong Zhang,Yufeng Zhang,Lin Cai,Yuanlong Xie
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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