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AB47864

Biotin Anti-Bradykinin antibody

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(2 Publications)

Rabbit Polyclonal Kininogen antibody - conjugated to Biotin. Suitable for IP, ELISA, RIA and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human KNG1 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

BDK, KNG, KNG1, Kininogen-1, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight kininogen, Williams-Fitzgerald-Flaujeac factor, HMWK

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Human

Applications

RIA, ELISA, IP

applications

Immunogen

Synthetic Peptide within Human KNG1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P01042

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "RIA-species-checked": "predicted", "RIA-species-dilution-info": "", "RIA-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "RIA-species-checked": "predicted", "RIA-species-dilution-info": "", "RIA-species-notes": "" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "RIA-species-checked": "predicted", "RIA-species-dilution-info": "", "RIA-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.5 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Bradykinin also known as bradykinin (BK) is a peptide that plays an important role in multiple physiological processes. Bradykinin consists of nine amino acids and typically has a molecular weight of around 1060 daltons. It is primarily expressed in endothelial cells and can be produced by blood plasma proteins in response to specific stimuli. Bradykinin exemplifies a mediator of inflammation and vasodilation contributing significantly to vascular permeability and lowering blood pressure.
Biological function summary

This peptide acts as an important modulator in inflammatory and pain processes. It forms part of the kallikrein-kinin system where it interacts with specific G-protein-coupled receptors known as bradykinin receptor B1 and B2. Bradykinin contributes to complex biological functions including the dilation of blood vessels smooth muscle contraction and activation of pain fiber nerve endings. This activity makes it critical for the body’s response to inflammation and injury.

Pathways

Bradykinin participates in the kallikrein-kinin system and the renin-angiotensin system. In the renin-angiotensin system bradykinin is related to angiotensin-converting enzyme (ACE) which degrades bradykinin and counters its vasodilatory effects. Bradykinin's role in inflammation and blood pressure regulation is linked closely to other vasoactive peptides and cytokines contributing to its importance in diverse physiological pathways.

Bradykinin is associated with conditions such as hereditary angioedema and chronic cough. In hereditary angioedema excessive bradykinin production leads to recurrent episodes of swelling due to its capacity to increase vascular permeability. The peptide also plays a role in inducing a chronic cough as an adverse reaction via its action on sensory neurons in the respiratory tract. This is often observed in patients using ACE inhibitors as the inhibition leads to increased levels of bradykinin.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.. Bradykinin. The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects : (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action).
See full target information KNG1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Open veterinary journal 13:150-170 PubMed37073241

2023

Long-term histological effects of high-dose prednisolone administration on the mitral valve in normal Beagle dogs.

Applications

Unspecified application

Species

Unspecified reactive species

Sachiyo Tanaka,Shuji Suzuki,Misaki Shimura,Asaka Kawana,Aki Tanaka,Satoshi Soeta,Yasushi Hara

Advances in clinical and experimental medicine : official organ Wroclaw Medical University 30:623-632 PubMed34018345

2021

Investigation of the role of miR-221 in diabetic peripheral neuropathy and related molecular mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaole Wu,Xiaoyu Wang,Yiyu Yin,Lei Zhu,Fengchao Zhang,Jianping Yang
View all publications
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