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AB95765

Biotin Anti-CD11c antibody [N418]

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(8 Publications)

Armenian hamster Monoclonal CD11c antibody - conjugated to Biotin. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 8 publications. Immunogen corresponding to Cell preparation containing Itgax protein.

View Alternative Names

CD11c, Integrin alpha-X, CD11 antigen-like family member C, Itgax

1 Images
Flow Cytometry - Biotin Anti-CD11c antibody [N418] (AB95765)
  • Flow Cyt

Supplier Data

Flow Cytometry - Biotin Anti-CD11c antibody [N418] (AB95765)

C57Bl/6 splenocytes were stained with APC-conjugated anti-MHC CLass II and 0.03μg ab95765 (right) or 0.03μg biotin-conjugated armenian hamster IgG isotype control (left), followed by streptavidin PE.

  • 667 PE/Cy5®

    PE/Cy5® Anti-CD11c antibody [N418]

  • 450 violetFluor™ 450

    violetFluor™ 450 Anti-CD11c antibody [N418]

  • 785 APC/Cy7®

    APC/Cy7® Anti-CD11c antibody [N418]

  • 660 APC

    APC Anti-CD11c antibody [N418]

  • 519 FITC

    FITC Anti-CD11c antibody [N418]

  • 578 PE

    PE Anti-CD11c antibody [N418]

  • 778 PE/Cy7®

    PE/Cy7® Anti-CD11c antibody [N418]

  • Unconjugated

    Anti-CD11c antibody [N418]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-CD11c antibody [N418]

  • 695 PerCP/Cy5.5®

    PerCP/Cy5.5® Anti-CD11c antibody [N418]

  • Carrier free

    Anti-CD11c antibody [N418] - Low endotoxin, Azide free

  • Carrier free

    Anti-CD11c antibody [N418] - BSA and Azide free

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-CD11c antibody [N418]

Key facts

Host species

Armenian hamster

Clonality

Monoclonal

Clone number

N418

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing Itgax protein. The exact immunogen used to generate this antibody is proprietary information.

Q9QXH4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.25-0.5 µg for 10^5-10^8 Cells", "FlowCyt-species-notes": "<p>Final volume of 100 μl.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.88% Sodium chloride, 0.12% Sodium dihydrogen phosphate, 0.1% Gelatin
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD11c also known as ITGAX is a subunit of integrin proteins that plays a pivotal role in immune cell function. This protein has a molecular mass of about 150 kDa and is primarily expressed on the surface of dendritic cells monocytes and macrophages. It serves as a marker for these cells commonly utilized in applications like CD11c flow cytometry and CD11c IHC. Researchers often study this target using CD11c antibodies to explore immune system dynamics and cell surface characteristics.
Biological function summary

CD11c functions as an integrin alpha X subunit forming a heterodimer with the beta 2 subunit known as ITGB2. This complex is important for cell adhesion and migration processes. It mediates the binding of leukocytes to endothelial cells facilitating their migration from the bloodstream to sites of inflammation or infection. CD11c's presence on immune cells makes it essential for presenting antigens and initiating immune responses therefore having critical implications for immunity.

Pathways

CD11c plays a significant role in the immune system particularly in the leukocyte adhesion and migration pathways. It partners with proteins like ITGB2 to mediate these functions. The signaling pathways involving CD11c and related molecules regulate leukocyte trafficking and activation ensuring proper localization and function at sites of damage or infection. These pathways are essential for maintaining immune homeostasis and prompt responses to pathogens.

CD11c has significant connections to autoimmune diseases and chronic inflammatory conditions. Aberrant CD11c expression or activity can contribute to the pathogenesis of conditions like rheumatoid arthritis where leukocyte migration and persistent inflammation play a role. Studies also link CD11c with proteins involved in these disorders highlighting its importance in disease progression and potential as a therapeutic target. The understanding of CD11c's role in these conditions can guide the development of treatments aimed at modulating immune responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis (By similarity).
See full target information Itgax
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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Journal of virology 80:11899-910 PubMed17005662

2006

Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ke-Qin Xin,Hiroaki Mizukami,Masashi Urabe,Yoshihiko Toda,Kaori Shinoda,Atsushi Yoshida,Kenji Oomura,Yoshitsugu Kojima,Motohide Ichino,Dennis Klinman,Keiya Ozawa,Kenji Okuda

The Journal of experimental medicine 203:2329-38 PubMed16966429

2006

Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Toshiaki Ohteki,Hiroyuki Tada,Kazuto Ishida,Taku Sato,Chikako Maki,Taketo Yamada,Junji Hamuro,Shigeo Koyasu

International immunology 18:1375-84 PubMed16849394

2006

The existence of CD11c+ sentinel and F4/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Zhang,Nobuyuki Kawashima,Hideaki Suda,Yukiko Nakano,Yoshiro Takano,Miyuki Azuma

Cancer research 65:3437-46 PubMed15833879

2005

Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection.

Applications

Unspecified application

Species

Unspecified reactive species

Cristiana Guiducci,Alain P Vicari,Sabina Sangaletti,Giorgio Trinchieri,Mario P Colombo

European journal of immunology 29:2148-55 PubMed10427977

1999

CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth.

Applications

Unspecified application

Species

Unspecified reactive species

C Esche,A Gambotto,Y Satoh,V Gerein,P D Robbins,S C Watkins,M T Lotze,M R Shurin

The Journal of experimental medicine 171:1753-71 PubMed2185332

1990

The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

J P Metlay,M D Witmer-Pack,R Agger,M T Crowley,D Lawless,R M Steinman

The Journal of small animal practice 20:41-56 PubMed759720

1979

Corneal pannus (chronic superficial keratitis) in the German shepherd dog.

Applications

Unspecified application

Species

Unspecified reactive species

P G Bedford,J A Longstaffe

Experimental eye research 25 Suppl:161-76 PubMed145370

1977

Secretion of the aqueous humour.

Applications

Unspecified application

Species

Unspecified reactive species

D F Cole
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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