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Mouse Monoclonal CD24 antibody - conjugated to Biotin. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Native Full Length Protein corresponding to Human CD24.

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Images

Flow Cytometry - Biotin Anti-CD24 antibody [SN3 A5-2H10] (AB95546), expandable thumbnail

Key facts

Isotype
IgG1
Host species
Mouse
Conjugation
Biotin
Storage buffer

pH: 7.2
Preservative: 0.09% Sodium azide

Form
Liquid
Clonality
Monoclonal

Immunogen

  • Native Full Length Protein corresponding to Human CD24. Database link P25063

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
Flow Cyt
Human
Tested

Tested
Tested

Species
Human
Dilution info
0.25 µg for 105 Cells
Notes

Cell number should be determined empirically but can range from 105 to 108 cells/test

ab18434 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Associated Products

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Target data

Function

May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).

Alternative names

CD24, CD24A, Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen

Recommended products

Mouse Monoclonal CD24 antibody - conjugated to Biotin. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Native Full Length Protein corresponding to Human CD24.

Key facts

Isotype
IgG1
Conjugation
Biotin
Form
Liquid
Clonality
Monoclonal
Immunogen
  • Native Full Length Protein corresponding to Human CD24. Database link P25063
Clone number
SN3 A5-2H10
Purification technique
Affinity purification Protein G
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

CD24 also known as heat-stable antigen or CD24A is a glycosylphosphatidylinositol (GPI)-anchored membrane protein with a molecular mass of approximately 30-50 kDa. It is expressed on the surface of many cell types including B cells T cells neutrophils and epithelial cells. CD24 plays a role in cell adhesion and signaling processes impacting immune response and cancer progression. Its expression is often used as a marker in identification and classification procedures such as flow cytometry.

Biological function summary

CD24 functions like a molecular "switch" modulating signals sent between cells. It acts as a ligand for multiple receptors and participates in cellular communication especially influencing the immune system. Part of its biological role involves interaction within cellular complexes impacting immune modulation and inflammatory responses. CD24's location at the interface of cellular microenvironments makes it critical for cellular response adaptation to varied external stimuli.

Pathways

CD24 participates in both immune signaling and cancer-related pathways. It plays a significant role in the suppression of the immune response often interacting with proteins like Siglec-10 in these pathways. CD24's involvement in these pathways contributes to cell survival and proliferation particularly within cancer development. The protein’s interaction within specified signaling pathways allows it to influence downstream targets that regulate gene expression and cellular functions.

Associated diseases and disorders

CD24 has significant connections to cancer and inflammatory diseases. It is highly expressed in various cancers including breast and prostate cancer where it correlates with poor prognosis due to its role in apoptosis evasion and metastasis. CD24 interacts with proteins like HMGB1 and is implicated in inflammatory conditions where it modulates immune cell activity. Extensive research into CD24's involvement in these disorders may lead to targeted therapies including the development of anti-CD24 antibodies for therapeutic interventions.

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1 product image

  • Flow Cytometry - Biotin Anti-CD24 antibody [SN3 A5-2H10] (ab95546), expandable thumbnail

    Flow Cytometry - Biotin Anti-CD24 antibody [SN3 A5-2H10] (ab95546)

    Staining of normal human peripheral blood cells with 0.125 µg of Mouse IgG1 ? Isotype Control Biotin (open histogram) or 0.125 µg of ab95546 (filled histogram) followed by Streptavidin PE. Cells in the large scatter population were used for analysis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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