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AB83439

Biotin Anti-FGF10 antibody

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(1 Publication)

Goat Polyclonal FGF10 antibody - conjugated to Biotin. Suitable for ELISA, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FGF10.

View Alternative Names

Fibroblast growth factor 10, FGF-10, Keratinocyte growth factor 2, FGF10

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Human

Applications

WB, ELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human FGF10.

O15520

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Alternative Products

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in PBS, 0.1% BSA
Purification technique
Affinity purification Immunogen
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGF10 also known as fibroblast growth factor 10 (FGF-10) is a member of the FGF family. It plays an important role in various developmental processes. It is a protein with a molecular mass of approximately 23 kDa. FGF10 is expressed in several tissues including the lungs limbs and salivary glands. Peprotech and recombinant versions of the FGF-10 protein are often utilized in research. In addition to its standard expression FGF10 is sometimes referenced in the context of biotin sublingual preparations which are used to study signaling processes more effectively.
Biological function summary

The FGF10 protein participates in important signaling necessary for embryonic development and tissue repair. It functions as a signaling molecule mediating interaction between epithelial and mesenchymal cells. FGF10 acts as a ligand for fibroblast growth factor receptor 2 (FGFR2) and is essential for limb bud formation and lung epithelium branching morphogenesis. This protein often works without forming part of a larger complex instead interacting with receptors directly to accomplish its functions.

Pathways

Fibroblast growth factor 10 is an integral part of the FGFR signaling pathway which is vital for cell proliferation differentiation and survival. Its interaction with FGFR2 activates downstream signaling cascades including the MAPK/ERK pathway. This involves related proteins such as FGFR1 and Ras important for transmitting extracellular signals to the nuclear environment affecting gene expression patterns essential for development and cell maintenance.

FGF10 has significant implications in pathologies such as lacrimo-auriculo-dento-digital (LADD) syndrome and congenital lung diseases. Mutations or dysregulation in FGF10 expression can lead to developmental abnormalities in the organs it helps form. LADD syndrome showcases its interplay with FGFR2 where mutations in FGF10 or its receptor are implicated in congenital features. Additionally abnormalities in its signaling can contribute to improper lung development where FGF10 again interacts prominently with proteins related to the FGFR family emphasizing its role in proper organogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
See full target information FGF10
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 31:107802 PubMed32579928

2020

Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development.

Applications

Unspecified application

Species

Unspecified reactive species

Tamihiro Kamata,Tsz Y So,Qasim Ahmed,Susan Giblett,Bipin Patel,Jinli Luo,Roger Reddel,Catrin Pritchard
View all publications
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Product promise

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