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AB48283

Biotin Anti-Gastrin antibody

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(1 Publication)

Anti-Gastrin antibody conjugated to Biotin is a rabbit polyclonal antibody suitable for ELISA, and reacts with human samples.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Human

Applications

ELISA

applications

Immunogen

Synthetic Peptide within Human GAST aa 50-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P01350

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Alternative Products

Primary Antibodies

AB53085

Anti-Gastrin antibody

Western blot - Anti-Gastrin antibody (AB53085)

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Primary Antibodies

AB232775

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastrin antibody (AB232775)

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Primary Antibodies

AB16036

Anti-Gastrin antibody, prediluted

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastrin antibody, prediluted (AB16036)

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Primary Antibodies

AB240980

Anti-Gastrin antibody [SP318] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastrin antibody [SP318] - BSA and Azide free (AB240980)

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Primary Antibodies

AB223501

Anti-Gastrin antibody [SP318]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastrin antibody [SP318] (AB223501)

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Complementary Products

Assay Kits

AB133033

Human Gastrin I ELISA Kit (GAST)

Competitive ELISA - Human Gastrin I ELISA Kit (GAST) (AB133033)

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Proteins & Peptides

AB131754

Recombinant Human Gastrin protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Gastrin protein (GST tag N-Terminus) (AB131754)

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Proteins & Peptides

AB42257

Human Gastrin peptide

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Primary Antibodies

AB307646

Anti-KMT6 / EZH2 antibody [EPR25353-284]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KMT6 / EZH2 antibody [EPR25353-284] (AB307646)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" }, "Cat": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "" }, "Pig": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.5 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Gastrin sometimes referred to as gastrin peptide is a hormone consisting of 34 amino acids with a molecular mass of approximately 3.8 kDa. This protein is mainly expressed in the G cells of the stomach lining specifically the antrum but also found in the duodenum and pancreas. Gastrin operates by stimulating the secretion of gastric acid from parietal cells in the stomach playing an important role in the digestive process. The presence of gastrin can be detected through various methods like gastrin stain and antibodies such as anti-gastrin are often used for this purpose.
Biological function summary

Gastrin impacts digestion and is an important promoter of gastric acid secretion and mucosal growth. Gastrin does not assemble into larger protein complexes functioning instead as an independent peptide hormone. It exerts its effects by binding to the cholecystokinin B receptor (CCK-B) on target cells leading to increased intracellular calcium levels and activation of protein kinases. The interaction initiates a cascade of events facilitating digestion by optimizing the stomach's environment.

Pathways

Gastrin has a significant role in the gastrointestinal (GI) pathway where it activates the secretion of hydrochloric acid. It also influences the phosphoinositide pathway through its relationship with G-proteins. The hormonal action of gastrin involves several other proteins like somatostatin which serves as an inhibitory counterpart and histamine that works synergistically by promoting further acid secretion through different receptors.

Physicians often study gastrin in relation to conditions like Zollinger-Ellison syndrome and peptic ulcers. Zollinger-Ellison syndrome leads to excessive production of gastrin causing severe ulcerations and gastric acid secretions. Concurrently elevated gastrin levels sometimes associate with tumors like gastrinomas. The interplay between gastrin and H. pylori infection is pivotal for peptic ulcer development where bacteria-induced inflammation could alter gastrin's normal regulatory functions of acid secretion.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
See full target information GAST

Alternative Names

GAS, GAST, Gastrin
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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

Neoplasia (New York, N.Y.) 15:1231-40 PubMed24339735

2013

Identification of molecular tumor markers in renal cell carcinomas with TFE3 protein expression by RNA sequencing.

Applications

Unspecified application

Species

Unspecified reactive species

Dorothee Pflueger,Andrea Sboner,Martina Storz,Jasmine Roth,Eva Compérat,Elisabeth Bruder,Mark A Rubin,Peter Schraml,Holger Moch
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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