Mouse Monoclonal IgA antibody - conjugated to Biotin. Suitable for ELISA and reacts with Common marmoset, Rhesus monkey, Human, Dog, Cat samples.
pH: 7.2
Preservative: 0.05% Sodium azide
Constituents: PBS
| ELISA | |
|---|---|
| Human | Expected |
| Cat | Expected |
| Common marmoset | Expected |
| Dog | Expected |
| Rhesus monkey | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Common marmoset, Rhesus monkey, Human, Dog, Cat | Dilution info Use at an assay dependent concentration. | Notes - |
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Hepatocellular carcinoma-associated protein TB6, Ig alpha 1 chain C region, Ig alpha 2 chain C region, Immunoglobulin heavy constant alpha 1, Immunoglobulin heavy constant alpha 2, Immunoglobulin heavy constant alpha 2 A2m marker, Poly-Ig receptor, polymeric immunoglobulin receptor, polymeric immunoglobulin receptor Secretory component
Mouse Monoclonal IgA antibody - conjugated to Biotin. Suitable for ELISA and reacts with Common marmoset, Rhesus monkey, Human, Dog, Cat samples.
pH: 7.2
Preservative: 0.05% Sodium azide
Constituents: PBS
ab53270 recognises IgA. It does not cross-react with IgG or IgM; it has been shown to detect secreted IgA in cat saliva and rhesus monkey jejunal washes
ab53270 is prepared by affinity chromatography on Protein A from tissue culture supernatant.
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Immunoglobulin A (IgA) also known as sIgA in its secretory form is an important component of the immune system. With a molecular weight of approximately 160 kDa IgA exists as a monomeric or dimeric structure. It is primarily expressed in mucosal areas such as the respiratory tract gastrointestinal tract and urogenital tract while also being present in secretions like saliva tears and breast milk. In its dimeric form IgA associates with a joining (J) chain and a secretory component which facilitates its transport across mucosal barriers.
IgA functions as a first line of defense in immune responses occurring at mucosal surfaces. Its primary role is to neutralize pathogens toxins and prevent their attachment and penetration through epithelial cells. This antibody does not form part of a larger complex but plays an important role in immune exclusion by trapping antigens in the mucus layer. Additionally IgA can mediate antibody-dependent cellular cytotoxicity and engage with specific receptors like FcαRI (CD89) on immune cells further enhancing its protective capabilities.
IgA participates in the mucosal immune response which is a sub-component of the broader immune system pathways. It is closely associated with the polymeric immunoglobulin receptor (pIgR) which transports IgA to the mucosal surfaces. The pathway involves recombination activation proteins (RAG) during its class-switching process in B cells differentiating from IgM-producing cells to those secreting IgA. These pathways are integral to maintaining the mucosal environment and protecting against pathogens.
Alterations or deficiencies in IgA can lead to increased susceptibility to infections and disorders like IgA nephropathy and celiac disease. In IgA nephropathy IgA deposits in the kidneys result in inflammation and damage to renal tissues. Celiac disease involves an immune reaction to gluten where IgA antibodies against tissue transglutaminase (tTG) contribute to intestinal damage. Both conditions illustrate the importance of IgA in maintaining immune balance and its connection with disease pathologies.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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