AB128731

Biotin Anti-IgA2 antibody [A9604D2]

Name: Biotin Anti-IgA2 antibody [A9604D2] (ab128731) | Abcam
Brand: Abcam Limited
SKU: AB128731

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(5 Publications)

Mouse Monoclonal IgA2 antibody - conjugated to Biotin. Suitable for ELISA, WB and reacts with Human samples. Cited in 5 publications.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

A9604D2

Isotype

IgG1

Conjugation

Biotin

Excitation/Emission

Carrier free

Reacts with

Human

Applications

WB, ELISA

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification notes

Purified IgG conjugated to Biotin

Storage buffer

Preservative: 0.09% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IgA2 also known as Immunoglobulin A2 is an antibody isotype mainly found in mucosal areas. It has a molecular mass of approximately 160 kDa. IgA2 is primarily expressed in the mucosal membranes lining the gut respiratory tract and urogenital tract playing an important role in the immune defense of these surfaces. It differs from IgA1 in the structure of the hinge region which is shorter and less likely to be cleaved by bacterial proteases providing enhanced protection at these sites.

Biological function summary

IgA2 serves as an essential component of the mucosal immune system. It forms complexes with antigenic substances to neutralize pathogens and prevent their adherence to epithelial cells. The dimeric form of IgA2 combined with the secretory component allows it to be effectively transported across mucosal barriers into secretions where it functions without activating complement pathways therefore reducing inflammation. The secretory IgA2 forms a physical barrier on mucosal surfaces trapping microbes and toxins.

Pathways

IgA2 functions within the mucosal immune response pathways and plays an important interaction role with components of the adaptive immune response. It associates with the polymeric immunoglobulin receptor (pIgR) facilitating its transcytosis across epithelial cells into secretions. IgA2 also operates within the immunological network alongside J chain proteins instrumental in forming its dimeric structure important for appropriate secretion and function in mucosal immunity.

IgA2 is connected to immunological conditions like IgA nephropathy and selective IgA deficiency. IgA nephropathy involves deposits of IgA in the kidneys which can lead to inflammatory kidney damage. In selective IgA deficiency individuals may have increased susceptibility to infections at mucosal surfaces due to decreased IgA levels wherein IgA2's role is significant. The interaction of IgA2 with other immunoglobulins becomes a factor in assessing these diseases especially with proteins that influence the immune response's regulation.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information IgA2

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 14:1080154 PubMed36911711

2023

Salivary IgA subtypes as novel disease biomarkers in systemic lupus erythematosus.

Applications

Unspecified application

Species

Unspecified reactive species

Sandra Romero-Ramírez,Víctor A Sosa-Hernández,Rodrigo Cervantes-Díaz,Daniel A Carrillo-Vázquez,David E Meza-Sánchez,Carlos Núñez-Álvarez,Jiram Torres-Ruiz,Diana Gómez-Martín,José L Maravillas-Montero

Frontiers in immunology 12:712130 PubMed34804008

2021

Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota.

Applications

Unspecified application

Species

Unspecified reactive species

Erick Sánchez-Salguero,Karina Corona-Cervantes,Hector Armando Guzmán-Aquino,María Fernanda de la Borbolla-Cruz,Víctor Contreras-Vargas,Alberto Piña-Escobedo,Jaime García-Mena,Leopoldo Santos-Argumedo

European journal of immunology 51:2641-2650 PubMed34398472

2021

Colostrum IgA1 antibodies recognize antigens from Helicobacter pylori and prevent cytoskeletal changesin human epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Shantal Lizbeth Baltierra-Uribe,Alejandra Montañez-Barragán,Héctor Romero-Ramírez,Ksenia Klimov-Kravtchenko,Karla Ivette Martínez-Pedro,Erick Sánchez-Salguero,Margarita Camorlinga-Ponce,Javier Torres,Leopoldo Santos-Argumedo

Maternal health, neonatology and perinatology 5:9 PubMed31205733

2019

Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum.

Applications

Unspecified application

Species

Unspecified reactive species

Erick Sánchez-Salguero,Geovanni Kaleb Mondragón-Ramírez,Julio C Alcántara-Montiel,Arturo Cérbulo-Vázquez,Xóchitl Villegas-Domínguez,Víctor Manuel Contreras-Vargas,María Del Rocío Thompson-Bonilla,Héctor Romero-Ramírez,Leopoldo Santos-Argumedo

Theranostics 7:4350-4358 PubMed29158831

2017

Identification and Validation of a Salivary Protein Panel to Detect Heart Failure Early.

Applications

Unspecified application

Species

Unspecified reactive species

Xi Zhang,Terry Walsh,John J Atherton,Karam Kostner,Benjamin Schulz,Chamindie Punyadeera

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Biotin Anti-IgA2 antibody [A9604D2]

Key facts

Host species

Clonality

Clone number

Isotype

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Alternative Products

Primary Antibodies

Primary Antibodies

Complementary Products

Primary Antibodies

Secondary Antibodies

Secondary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Product promise