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Rabbit Recombinant Monoclonal IL2RA antibody - conjugated to Biotin. Suitable for sELISA and reacts with Human samples.

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Key facts

Isotype

IgG

Host species

Rabbit

Conjugation

Biotin

Storage buffer

pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA

Form

Liquid

Clonality

Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
sELISA
Human
Expected

Expected
Expected

Species

Human

Dilution info

Use at an assay dependent concentration.

Notes

-

Target data

Function

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

Alternative names

Rabbit Recombinant Monoclonal IL2RA antibody - conjugated to Biotin. Suitable for sELISA and reacts with Human samples.

Key facts

Isotype

IgG

Conjugation

Biotin

Form

Liquid

Clonality

Monoclonal

Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Clone number

EPR23862-65

Purification technique

Affinity purification Protein A

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle, Store in the dark

Notes

This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

IL2RA also known as CD25 or interleukin-2 receptor alpha chain is a protein that performs an important role in the immune system. It has a molecular mass of approximately 55 kDa. This protein is expressed mainly by activated T cells regulatory T cells and recent thymic emigrants. IL2RA forms an important part of the high-affinity IL-2 receptor complex which also includes the beta and gamma chains. The presence of IL2RA ensures effective signaling and response to interleukin-2 a cytokine that promotes the proliferation and differentiation of immune cells.

Biological function summary

IL2RA engages in modulating the immune response as it acts in the high-affinity interleukin-2 receptor complex. It enables the IL-2 signaling that supports the development and expansion of T cells including regulatory T cells which help in maintaining immune tolerance. This receptor plays a fundamental role in T-cell fostered adaptive immunity facilitating the communication between cells that regulate immune responses. By regulating these processes IL2RA maintains balance in the immune system and prevents overactivation.

Pathways

Researchers recognize IL2RA as an essential participant in the JAK-STAT signaling pathway and the MAPK pathway. These pathways promote cellular responses such as growth proliferation and apoptosis which are important for immune function and homeostasis. IL2RA initiates signaling cascades through interaction with the interleukin-2 receptor beta (CD122) and common gamma chain (CD132) illustrating its direct link with these related proteins that manage immune response activities.

Associated diseases and disorders

IL2RA has implications in autoimmune diseases like multiple sclerosis and type 1 diabetes where immune cell regulation becomes dysregulated. Dysregulation or mutations in IL2RA can impair its ability to modulate immune responses thereby leading to such autoimmune conditions. Furthermore IL2RA's interaction with other proteins like CD122 and CD132 hints at potential therapeutic targets as these proteins play roles in the disease pathways affecting immune system balance and function.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
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    Product protocols

    For this product, it's our understanding that no specific protocols are required. You can:

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