Rabbit Recombinant Monoclonal IL2RA antibody - conjugated to Biotin. Suitable for sELISA and reacts with Human samples.
IgG
Rabbit
Biotin
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Liquid
Monoclonal
sELISA | |
---|---|
Human | Expected |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, TAC antigen, p55, IL2RA, CD25
Rabbit Recombinant Monoclonal IL2RA antibody - conjugated to Biotin. Suitable for sELISA and reacts with Human samples.
IgG
Rabbit
Biotin
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Liquid
Monoclonal
EPR23862-65
Affinity purification Protein A
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle, Store in the dark
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
This supplementary information is collated from multiple sources and compiled automatically.
IL2RA also known as CD25 or interleukin-2 receptor alpha chain is a protein that performs an important role in the immune system. It has a molecular mass of approximately 55 kDa. This protein is expressed mainly by activated T cells regulatory T cells and recent thymic emigrants. IL2RA forms an important part of the high-affinity IL-2 receptor complex which also includes the beta and gamma chains. The presence of IL2RA ensures effective signaling and response to interleukin-2 a cytokine that promotes the proliferation and differentiation of immune cells.
IL2RA engages in modulating the immune response as it acts in the high-affinity interleukin-2 receptor complex. It enables the IL-2 signaling that supports the development and expansion of T cells including regulatory T cells which help in maintaining immune tolerance. This receptor plays a fundamental role in T-cell fostered adaptive immunity facilitating the communication between cells that regulate immune responses. By regulating these processes IL2RA maintains balance in the immune system and prevents overactivation.
Researchers recognize IL2RA as an essential participant in the JAK-STAT signaling pathway and the MAPK pathway. These pathways promote cellular responses such as growth proliferation and apoptosis which are important for immune function and homeostasis. IL2RA initiates signaling cascades through interaction with the interleukin-2 receptor beta (CD122) and common gamma chain (CD132) illustrating its direct link with these related proteins that manage immune response activities.
IL2RA has implications in autoimmune diseases like multiple sclerosis and type 1 diabetes where immune cell regulation becomes dysregulated. Dysregulation or mutations in IL2RA can impair its ability to modulate immune responses thereby leading to such autoimmune conditions. Furthermore IL2RA's interaction with other proteins like CD122 and CD132 hints at potential therapeutic targets as these proteins play roles in the disease pathways affecting immune system balance and function.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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