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AB322821

Biotin Anti-IL2RA antibody [EPR23862-65] (Detector)

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Rabbit Recombinant Monoclonal IL2RA antibody - conjugated to Biotin. Suitable for sELISA and reacts with Human samples.

View Alternative Names

CD25, Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, TAC antigen, p55, IL2RA

  • Carrier free

    Anti-IL2RA antibody [EPR23862-65] - BSA and Azide free (Detector)

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR23862-65

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Complementary Products

Assay Kits

AB283543

Human IL-2 Receptor alpha ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human IL-2 Receptor alpha ELISA Kit (AB283543)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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Product details

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IL2RA also known as CD25 or interleukin-2 receptor alpha chain is a protein that performs an important role in the immune system. It has a molecular mass of approximately 55 kDa. This protein is expressed mainly by activated T cells regulatory T cells and recent thymic emigrants. IL2RA forms an important part of the high-affinity IL-2 receptor complex which also includes the beta and gamma chains. The presence of IL2RA ensures effective signaling and response to interleukin-2 a cytokine that promotes the proliferation and differentiation of immune cells.
Biological function summary

IL2RA engages in modulating the immune response as it acts in the high-affinity interleukin-2 receptor complex. It enables the IL-2 signaling that supports the development and expansion of T cells including regulatory T cells which help in maintaining immune tolerance. This receptor plays a fundamental role in T-cell fostered adaptive immunity facilitating the communication between cells that regulate immune responses. By regulating these processes IL2RA maintains balance in the immune system and prevents overactivation.

Pathways

Researchers recognize IL2RA as an essential participant in the JAK-STAT signaling pathway and the MAPK pathway. These pathways promote cellular responses such as growth proliferation and apoptosis which are important for immune function and homeostasis. IL2RA initiates signaling cascades through interaction with the interleukin-2 receptor beta (CD122) and common gamma chain (CD132) illustrating its direct link with these related proteins that manage immune response activities.

IL2RA has implications in autoimmune diseases like multiple sclerosis and type 1 diabetes where immune cell regulation becomes dysregulated. Dysregulation or mutations in IL2RA can impair its ability to modulate immune responses thereby leading to such autoimmune conditions. Furthermore IL2RA's interaction with other proteins like CD122 and CD132 hints at potential therapeutic targets as these proteins play roles in the disease pathways affecting immune system balance and function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
See full target information IL2RA
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com