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AB193426

Biotin Anti-Interferon gamma antibody

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(2 Publications)

Rabbit Polyclonal Interferon gamma antibody - conjugated to Biotin. Suitable for WB and reacts with Guinea pig samples. Cited in 2 publications.
1 Images
Western blot - Biotin Anti-Interferon gamma antibody (AB193426)
  • WB

Supplier Data

Western blot - Biotin Anti-Interferon gamma antibody (AB193426)

All lanes:

Western blot - Biotin Anti-Interferon gamma antibody (ab193426) at 2 µg/mL

All lanes:

Recombinant Guinea Pig Interferon gamma protein at 10 µg

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 19 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Guinea pig

Applications

WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Guinea pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Precipitation Caprylic Acid and Ammonium Sulphate
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Interferon gamma (IFN-γ) also known as type II interferon is a cytokine that plays an important role in immune response. IFN-γ has a molecular weight of about 17 kDa and is produced by T cells and natural killer (NK) cells. IFN-γ binds to the interferon gamma receptor initiating a signaling cascade that activates various genes involved in immune functions. It is expressed mainly in activated immune cells within lymphoid tissues and inflamed sites during immune responses.
Biological function summary

This cytokine is significant in promoting macrophage activation enhancing the antigen presentation process and boosting the antimicrobial activity of phagocytes. IFN-γ is not part of a larger protein complex but works as a homodimer in signal transduction. Its production heightens the Th1 immune response by stimulating the differentiation of naïve T cells into Th1 cells which is essential for effective cellular immunity.

Pathways

IFN-γ is integrally involved in the JAK-STAT signaling pathway alongside another critical cytokine Interleukin-12. This pathway further amplifies the immune response by regulating the expression of genes associated with cellular defense mechanisms. IFN-γ also interacts with the NF-kB pathway influencing inflammation and the activation of further immune responses. These interactions show a network of cooperativity with proteins like STAT1 and NF-kB essential for executing its biological roles.

IFN-γ is linked to autoimmune diseases such as rheumatoid arthritis and multiple sclerosis where its elevated levels can exacerbate inflammatory processes. It connects to other proteins like TNF-alpha in promoting the inflammatory cascade. Moreover lower levels of IFN-γ are associated with a heightened risk of infections like tuberculosis demonstrating its vital role in pathogen defense. Therefore understanding IFN-γ and its interactions can be key in developing therapeutic approaches against these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information IFNG
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:752 PubMed38272918

2024

MHC-I upregulation safeguards neoplastic T cells in the skin against NK cell-mediated eradication in mycosis fungoides.

Applications

Unspecified application

Species

Unspecified reactive species

Yun-Tsan Chang,Pacôme Prompsy,Susanne Kimeswenger,Yi-Chien Tsai,Desislava Ignatova,Olesya Pavlova,Christoph Iselin,Lars E French,Mitchell P Levesque,François Kuonen,Malgorzata Bobrowicz,Patrick M Brunner,Steve Pascolo,Wolfram Hoetzenecker,Emmanuella Guenova

The Journal of pharmacy and pharmacology 72:956-968 PubMed32314371

2020

Tectorigenin inhibits inflammation and pulmonary fibrosis in allergic asthma model of ovalbumin-sensitized guinea pigs.

Applications

Unspecified application

Species

Unspecified reactive species

Youpeng Wang,Weichao Jing,Wanying Qu,Zhiwei Liu,Di Zhang,Xiaoyu Qi,Lujia Liu
View all publications
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