Biotin Anti-Ki67 antibody [MKI67/2465]
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(1 Publication)
Mouse Monoclonal Ki67 antibody - conjugated to Biotin. Suitable for Protein Array, IHC-P and reacts with Recombinant full length protein - Human, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MKI67 aa 2250-2500.
View Alternative Names
Proliferation marker protein Ki-67, Antigen identified by monoclonal antibody Ki-67, Antigen KI-67, Antigen Ki67, MKI67
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Biotin Anti-Ki67 antibody [MKI67/2465] (AB271811)
Formalin-fixed, paraffin-embedded human tonsil tissue stained for Ki67 using ab271811 at 4 μg/ml in immunohistochemical analysis.
- Protein Array
Supplier Data
Protein Array - Biotin Anti-Ki67 antibody [MKI67/2465] (AB271811)
Analysis of Protein Array containing more than 19,000 full-length human proteins using ab271811.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Related conjugates and formulations (1)
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Anti-Ki67 antibody [MKI67/2465]
Reactivity data
Properties and storage information
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The Ki67 protein plays an essential role in cellular proliferation processes. It does not form part of a stable complex but interacts transiently with other cell cycle-related proteins. Research indicates that Ki67 maintains the structure of the perichromosomal layer during mitosis impacting chromosome separation. It is particularly active in tissues with high cell turnover such as bone marrow and lymphoid organs.
Pathways
Ki67 influences several key cellular pathways that control cell proliferation and differentiation. The protein acts within the regulation of the cell cycle and the PI3K/AKT signaling pathway important for cell growth and survival. Within these pathways Ki67 interacts with proteins like cyclin-dependent kinases (CDKs) which regulate transitions between different phases of the cell cycle.
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Target data
Publications (1)
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Journal of immunology research 2022:3351268 PubMed35571569
2022
Applications
Unspecified application
Species
Unspecified reactive species
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