Biotin Anti-M-CSF/CSF1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

M-CSF also called CSF1 or macrophage colony-stimulating factor is a cytokine with a molecular mass of approximately 40 kDa. It plays a significant role in the regulation of macrophage production differentiation and function. M-CSF is expressed in various tissues including the bone marrow spleen and liver. The expression of this cytokine is pivotal for the development and survival of mononuclear phagocytes and is critical in myeloid lineage regulation.

Biological function summary

This cytokine functions as a growth factor that influences the survival proliferation and differentiation of hematopoietic progenitor cells into mature macrophages. M-CSF forms a homodimeric complex that interacts with its receptor c-Fms which is a cell surface glycoprotein expressed on monocytes and macrophages. This interaction is essential for signal transduction that leads to the activation of pathways involved in cell growth and proliferation. Unlike some other growth factors M-CSF does not require the presence of a co-factor to exert its effects on target cells.

Pathways

M-CSF is involved in the MAPK/ERK and PI3K/AKT signaling pathways. These pathways are critical for the mediation of cell proliferation and survival. Within these pathways M-CSF connects with other proteins such as AKT1 and MAPK1 which further transduce signals that aid in cellular growth and immune response regulation. M-CSF also interacts through its receptor c-Fms which propagates downstream signaling ensuring the appropriate activation of macrophage-related pathways.

Associated diseases and disorders

An imbalance or dysregulation of M-CSF activity has been linked to disorders such as osteoporosis and certain cancers. Osteoporosis involves excessive bone resorption due to increased osteoclast activity where M-CSF participates in osteoclast differentiation. In cancer particularly breast and prostate cancer M-CSF expression supports tumor-associated macrophages promoting tumor progression. Additionally c-Fms is involved in these disease processes creating a significant therapeutic target for modulating M-CSF activity to potentially alleviate symptoms or halt disease progression.