Biotin Anti-M13 antibody [E1]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The target 'M13' also known as M13 bacteriophage is a filamentous bacteriophage with a mass of approximately 2 MDa. This bacteriophage infects Escherichia coli bacteria and is characterized by a cylindrical shape with helical symmetry. The M13 phage expresses a protein coat made up of thousands of coat proteins including major coat protein g8p and minor proteins like g3p at its ends. These proteins interact with the bacterial surface for infection.

Biological function summary

M13 phage serves as a tool in phage display technology facilitating the identification of peptide-protein interactions. It does not actively participate in cellular processes but can be part of complex interactions in biotechnological applications. In contrast to lytic phages M13 allows for the continued survival of its host leading to its utilization in non-destructive recombinant DNA methodologies.

Pathways

M13 phage does not integrate into traditional metabolic or signaling pathways of the bacterial host. Instead it exploits the host's machinery for its replication and assembly. Not directly related to human biological pathways its use in phage display allows exploring interactions involving proteins such as antibodies or enzymes including the anti M13 HRP.

Associated diseases and disorders

M13 phage does not directly relate to human diseases but it is essential in diagnostics and therapeutic antibody development. Researchers use phage display libraries to identify antibodies against targets involved in cancer and autoimmune diseases. The interaction between M13 and the Fc region of antibodies is exploited aiding in the precise selection of antibody fragments for therapeutic applications.