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AB39627

Biotin Anti-MCP2 antibody

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(1 Publication)

Rabbit Polyclonal MCP2 antibody - conjugated to Biotin. Suitable for WB, sELISA and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Ccl8.

View Alternative Names

Mcp2, Scya8, Ccl8, C-C motif chemokine 8, Monocyte chemoattractant protein 2, Monocyte chemotactic protein 2, Small-inducible cytokine A8, MCP-2

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Mouse

Applications

WB, sELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Ccl8.

Q9Z121

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Alternative Products

Primary Antibodies

AB155966

Anti-MCP2 antibody [EPR10151]

RabMAb|Recombinant

Western blot - Anti-MCP2 antibody [EPR10151] (AB155966)

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Primary Antibodies

AB155967

Anti-MCP2 antibody [EPR10150]

RabMAb|Recombinant

Western blot - Anti-MCP2 antibody [EPR10150] (AB155967)

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Complementary Products

Assay Kits

AB203366

Mouse MCP2 ELISA Kit (CCL8)

Recombinant|SimpleStep

Sandwich ELISA - Mouse MCP2 ELISA Kit (CCL8) (AB203366)

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  • 1
Primary Antibodies

AB317579

Anti-CCXCR1/XCR1 antibody [CIA207A] - BSA and Azide free

BOND RX™ Validated|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCXCR1/XCR1 antibody [CIA207A] - BSA and Azide free (AB317579)

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  • 0
Assay Kits

AB203366

Mouse MCP2 ELISA Kit (CCL8)

Recombinant|SimpleStep

Sandwich ELISA - Mouse MCP2 ELISA Kit (CCL8) (AB203366)

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  • 1
Primary Antibodies

AB270321

Anti-XCL1 antibody [EPR22634-114] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-XCL1 antibody [EPR22634-114] - BSA and Azide free (Detector) (AB270321)

  • 0
  • 0
Primary Antibodies

AB18207

Anti-beta III Tubulin antibody - Neuronal Marker

BOND RX™ Validated|Lab Essentials|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-beta III Tubulin antibody - Neuronal Marker (AB18207)

  • 5
  • 67
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute to a concentration of 50µg/ml with sterile PBS solution containing 0.1% BSA
Purification technique
Affinity purification Immunogen
Storage buffer
Constituents: PBS, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MCP2 also known as CCL8 or monocyte chemoattractant protein-2 plays an important role in leukocyte trafficking. This chemokine has a molecular weight of approximately 8 kDa. CCL8 is expressed in various tissues including macrophages fibroblasts and endothelial cells and it is particularly high during inflammatory responses. The MCP2 protein attracts immune cells such as monocytes and T cells to sites of infection or injury.
Biological function summary

MCP2 influences the migration and activation of leukocytes enhancing the body's immune response. MCP2 interacts with chemokine receptors like CCR2 and CCR5 facilitating the movement of immune cells through tissues. This protein is not usually part of larger complexes but works closely with other chemokines to coordinate cellular responses during inflammation. MCP2 activity is important in processes that require rapid cell recruitment and immune surveillance.

Pathways

MCP2 functions within the chemokine signaling pathway and plays a significant part in the inflammatory response pathway. MCP2 closely interacts with chemokine receptors such as CCR2 which is also engaged by related chemokines like MCP1 (CCL2). MCP2 and MCP1 share functional similarities in modulating the immune response though they target different receptor profiles that expand their influence across numerous immune processes.

MCP2 is associated with inflammatory diseases and certain types of cancer. Rheumatoid arthritis shows heightened levels of MCP2 contributing to the persistent inflammation characteristic of the disorder. Elevated MCP2 levels have also been noticed in tumor microenvironments suggesting a role in cancer metastasis where it might interact with proteins such as IL-6 to promote the survival and migration of tumor cells.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity).
See full target information Ccl8
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Respiratory research 25:428 PubMed39633343

2024

T follicular helper cell is essential for M2 macrophage polarization and pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Cheng Li,Pingping Liu,Hao Zhu,Huan Yang,Jun Zha,Huiling Yao,Shaoze Zhang,Jin Huang,Guang Li,Gang Jiang,Yongliang Jiang,Aiguo Dai
View all publications
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Product promise

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