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AB271274

Biotin Anti-Neurotrophin 3 antibody

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Rabbit Polyclonal Neurotrophin 3 antibody - conjugated to Biotin. Suitable for ELISA and reacts with Recombinant fragment - Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human NTF3 aa 100 to C-terminus.

View Alternative Names

Neurotrophin-3, NT-3, HDNF, Nerve growth factor 2, Neurotrophic factor, NGF-2, NTF3

1 Images
ELISA - Biotin Anti-Neurotrophin 3 antibody (AB271274)
  • ELISA

Supplier Data

ELISA - Biotin Anti-Neurotrophin 3 antibody (AB271274)

Human Neurotrophin 3 was detected by sandwich ELISA (using 100 μl/well) using a concentration of 0.25-1.0 μg/ml of ab271274. This antibody in conjunction with an appropriate capture antibody, allows the detection of at least 0.2-0.4 ng/well of recombinant Neurotrophin 3 protein.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Applications

ELISA

applications

Immunogen

Recombinant Fragment Protein within Human NTF3 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P20783

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Human": { "ELISA-species-checked": "testedAndGuaranteed", "ELISA-species-dilution-info": "0.25-1 µg/mL", "ELISA-species-notes": "<p>Human NT-3<strong> </strong>was detected by sandwich ELISA (using 100μl/well) using a concentration of 0.25-1.0 μg/ml of ab271274. This antibody in conjunction with an appropriate capture antibody, allows the detection of at least 0.2 – 0.4 ng/well of recombinant hNT-3 protein.</p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in PBS, 0.1% BSA
Purification technique
Affinity purification
Storage buffer
Constituents: PBS, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neurotrophin 3 also known as NT-3 or neurotrophin-3 is a protein with a molecular mass around 28 kDa. It belongs to the neurotrophin family and acts mechanically by binding to specific tyrosine kinase receptors especially TrkC on target cells. This binding initiates intracellular signaling cascades essential for neuronal development and survival. NT-3 is expressed in the central and peripheral nervous systems and is involved in various cellular processes. Expression levels can vary depending upon developmental stages and types of nervous tissue.
Biological function summary

NT-3 has a role in the survival and differentiation of neurons especially sensory ganglia neurons. It supports the development and maintenance of the nervous system by influencing neuron growth and plasticity. While not typically forming a large protein complex NT-3 interacts with its receptor TrkC to transmit critical signals internally. Such interactions can modulate synaptic responses and connectivity ultimately influencing learning and memory formation. NT-3 also interacts with p75NTR another receptor though this interaction is less specific compared to its action on TrkC.

Pathways

NT-3 participates in the MAPK/ERK signaling and PI3K/AKT pathways. These pathways are fundamental in regulating cell differentiation growth and survival. They also mediate a variety of cellular responses to external stimuli. NT-3's activation of the TrkC receptor triggers these pathways affecting other proteins such as BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) which are part of the neurotrophin family. The intricate web of interactions highlights NT-3's significance in pathway modulation involved in neurodevelopment and plasticity.

NT-3 has implications in neurodegenerative diseases like Parkinson’s disease and Huntington's disease. The protein’s role in supporting neuronal survival points to its potential impact when its signaling is disrupted or deficient. NT-3 exhibits connections with proteins such as TrkC and BDNF which are also related to these neurodegenerative disorders. Dysfunctional NT-3-TrkC signaling could contribute to disease progression by impairing neuronal survival or recovery. Understanding NT-3's role in these contexts can offer insights into therapeutic approaches for such conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Seems to promote the survival of visceral and proprioceptive sensory neurons.
See full target information NTF3
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Product promise

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