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AB27646

Biotin Anti-Nitrotyrosine antibody

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(2 Publications)

Goat Polyclonal Nitrotyrosine antibody - conjugated to Biotin. Suitable for ELISA, WB and reacts with Chemical samples. Cited in 2 publications. Immunogen corresponding to Chemical / Small Molecule corresponding to Nitrotyrosine.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Applications

WB, ELISA

applications

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AB75769

Anti-CD146 antibody [EPR3208]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification notes
Purified by nitrated protein-Sepharose™
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.02% Sodium azide Constituents: 0.73% Disodium hydrogenorthophosphate, 0.45% Sodium chloride, 0.27% Sodium dihydrogen phosphate, 0.02% Ethylenediaminetetraacetic acid, disodium, dihydrate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Nitrotyrosine also known as 3-nitrotyrosine is a marker for nitrosative stress and oxidative damage. It comes from the nitration of tyrosine an amino acid primarily through the action of reactive nitrogen species. Nitrotyrosine can be found in proteins and its molecular mass varies depending on the protein context. It is present across various tissues and fluid samples within the body particularly where high oxidative stress occurs.
Biological function summary

Nitrotyrosine acts as an indicator of cellular damage and protein modification due to stress conditions. When proteins have nitrotyrosine residues their function might change which can lead to cellular signaling disruption. Nitrotyrosine is not usually part of a specific complex but it affects proteins and enzymes by altering their activity and stability contributing to larger stress response mechanisms.

Pathways

Proteins modified by nitrotyrosine are involved in cellular pathways related to oxidative stress and inflammation. Particularly pathways like the nitric oxide synthase pathway and the inflammatory response pathway include nitrotyrosine-modified proteins. It is related to proteins such as nitric oxide synthase (NOS) and superoxide dismutase (SOD) important in managing oxidative balance and stress responses in cells.

Nitrotyrosine is significantly linked to diseases related to oxidative stress such as cardiovascular disease and neurodegenerative disorders. These conditions often have increased levels of nitrotyrosine indicating heightened oxidative damage. Through these diseases nitrotyrosine connects with proteins like amyloid-beta in neurodegenerative disorders and endothelial nitric oxide synthase (eNOS) in cardiovascular diseases reflecting the impact of oxidative stress on these proteins.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Nitrotyrosine
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Arthritis research & therapy 19:287 PubMed29273092

2017

Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study.

Applications

Unspecified application

Species

Unspecified reactive species

Isabel Ferreira,Sara Croca,Maria Gabriella Raimondo,Manjit Matharu,Sarah Miller,Ian Giles,David Isenberg,Yiannis Ioannou,John G Hanly,Murray B Urowitz,Nicole Anderson,Cynthia Aranow,Anca Askanase,Sang-Cheol Bae,Sasha Bernatsky,Ian N Bruce,Jill Buyon,Ann E Clarke,Mary Anne Dooley,Paul Fortin,Ellen Ginzler,Dafna Gladman,Caroline Gordon,Murat Inanc,Søren Jacobsen,Kenneth Kalunian,Diane Kamen,Munther Khamashta,Sam Lim,Susan Manzi,Joan Merrill,Ola Nived,Christine Peschken,Michelle Petri,Rosalind Ramsey-Goldman,Guillermo Ruiz-Irastorza,Jorge Sanchez-Guerrero,Kristjan Steinson,Gunnar K Sturfelt,Ronald van Vollenhoven,Daniel J Wallace,Asad Zoma,Anisur Rahman

Arthritis research & therapy 16:R48 PubMed24502558

2014

Serum nitrated nucleosome levels in patients with systemic lupus erythematosus: a retrospective longitudinal cohort study.

Applications

ELISA

Species

Human

Sara Croca,Paul Bassett,Charis Pericleous,Karim Fouad Alber,David Latchman,David Isenberg,Ian Giles,Anisur Rahman,Yiannis Ioannou
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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